Inbred lines of mice derived from long-term growth selected lines: unique resources for mapping growth genes

L Bunger, Anita Helen Laidlaw, G Bulfield, EJ Eisen, JF Medrano, GE Bradford, F Pirchner, U Renne, W Schlote, WG Hill

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Lines of mice selected for many generations for high or low growth in several laboratories around the world have been collected, and from these, inbred lines are being developed by recurrent full-sib mating in Edinburgh. There are seven high selected lines and four low lines (each low line is from the same base population as one of the high lines), and the histories of each are summarized. Mean body weight of males at 70 days of age in the Edinburgh laboratory in the heaviest inbred line (77 g) is 4.8-fold higher than in the lightest line (16 g), and 1.9-fold higher than in the least extreme high line (41 g). Litter size, food intake, and fat content also differ substantially. These inbred extreme selected lines are a uniquely valuable resource for QTL or gene mapping, candidate gene identification, and elucidation of epistatic effects.
Original languageEnglish
Pages (from-to)678 - 686
Number of pages9
JournalMammalian Genome
Volume12
Issue number9
DOIs
Publication statusPublished - Sept 2001

Keywords

  • QUANTITATIVE TRAIT LOCI
  • 8-WEEK BODY-WEIGHT
  • DIVERGENT SELECTION
  • LABORATORY-ANIMALS
  • OBESITY GENES
  • MOUSE LINES
  • FAT-CONTENT
  • FOOD-INTAKE
  • RAPID GAIN
  • HORMONE

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