In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria

Rona R. Ramsay*, Mohamed S. Rashed, Sidney D. Nelson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Acetaminophen, an analgesic and antipyretic, is toxic in overdose to liver and kidney. The effects on mitochondrial respiration of acetaminophen, its less toxic analog, 3-hydroxyacetanilide, and metabolites which arise from these compounds have been investigated. The parent compounds inhibited NADH-linked respiration reversibly, whereas the metabolites inhibit all mitochondrial respiration, apparently in the Complex III region of the respiratory chain. The quinone derivatives, 4-acetamido-o-benzoquinone and 2-acetamido-p-benzoquinone, are the best inhibitors, with the onset of inhibition dependent on active respiration, suggesting interaction of these compounds with oxidized components of the electron transport chain.

Original languageEnglish
Pages (from-to)449-457
Number of pages9
JournalArchives of Biochemistry and Biophysics
Volume273
Issue number2
DOIs
Publication statusPublished - 1 Jan 1989

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