Impact of azithromycin administration for trachoma control on the carriage of antibiotic-resistant Streptococcus pneumoniae

Sarah L. Batt, Bambos M. Charalambous, Anthony W. Solomon, Charles Knirsch, Patrick A. Massae, Salesia Safari, Noel E. Sam, Dean Everett, David C.W. Mabey, Stephen H. Gillespie*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Community distribution of azithromycin has an important role to play in trachoma control. Previous studies have suggested that this may increase the prevalence of macrolide-resistant Streptococcus pneumoniae. S. pneumoniae was isolated from children under 7 years of age in Rombo District, northern Tanzania, before and 2 and 6 months after community-wide administration of azithromycin. Overall carriage rates were 11, 12, and 7%, respectively. Only one macrolide-resistant isolate carrying the mef gene was obtained 6 months after azithromycin administration. This contrasted with cotrimoxazole and penicillin resistance, both of which were common (cotrimoxazole resistance, 42, 43, and 47%, and penicillin resistance, 21, 17, and 16% at baseline, 2 months, and 6 months, respectively). There was a significant association between cotrimoxazole and penicillin resistance (P < 0.0001, Fisher's exact). These data suggest that in communities where macrolide resistance is rare, azithromycin distribution for trachoma control is unlikely to increase the prevalence of resistant organisms.

Original languageEnglish
Pages (from-to)2765-2769
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number9
DOIs
Publication statusPublished - 1 Sept 2003

Fingerprint

Dive into the research topics of 'Impact of azithromycin administration for trachoma control on the carriage of antibiotic-resistant Streptococcus pneumoniae'. Together they form a unique fingerprint.

Cite this