TY - JOUR
T1 - Immune cell composition varies by age, sex and exposure to social adversity in free‑ranging Rhesus Macaques
AU - Sanchez-Rosado, Mitchell R.
AU - Marzan-Rivera, Nicole
AU - Watowich, Marina M.
AU - Negron-Del Valle, Andrea D.
AU - Pantoja, Petraleigh
AU - Pavez-Fox, Melissa A.
AU - Siracusa, Erin R.
AU - Cooper, Eve B.
AU - Negron-Del Valle, Josue E.
AU - Phillips, Daniel
AU - Ruiz-Lambides, Angelina
AU - Martinez, Melween I.
AU - Montague, Michael J.
AU - Platt, Michael L.
AU - Higham, James P.
AU - Brent, Lauren J.N.
AU - Sariol, Carlos A.
AU - Snyder-Mackler, Noah
N1 - Funding: This work was supported by the National Institutes of Health (R01-AG060931; R01-AG060931-S1; R00-AG051764; R01-MH118203; R01-MH096875; R56-AG071023; F31-AG072787; R36-AG080081; C06-OD026690; P40-OD012217; NSF-1800558; ERC-864461).
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Increasing age is associated with dysregulated immune function and
increased inflammation—patterns that are also observed in individuals
exposed to chronic social adversity. Yet we still know little about how
social adversity impacts the immune system and how it might promote
age-related diseases. Here, we investigated how immune cell diversity
varied with age, sex and social adversity (operationalized as low social
status) in free-ranging rhesus macaques. We found age-related
signatures of immunosenescence, including lower proportions of CD20 + B
cells, CD20 + /CD3 + ratio, and CD4 + /CD8 + T cell ratio – all signs of
diminished antibody production. Age was associated with higher
proportions of CD3 + /CD8 + Cytotoxic T cells, CD16 + /CD3- Natural
Killer cells, CD3 + /CD4 + /CD25 + and CD3 + /CD8 + /CD25 + T cells, and
CD14 + /CD16 + /HLA-DR + intermediate monocytes, and lower levels of
CD14 + /CD16-/HLA-DR + classical monocytes, indicating greater amounts
of inflammation and immune dysregulation. We also found a sex-dependent
effect of exposure to social adversity (i.e., low social status).
High-status males, relative to females, had higher CD20 + /CD3 + ratios
and CD16 + /CD3 Natural Killer cell proportions, and lower proportions
of CD8 + Cytotoxic T cells. Further, low-status females had higher
proportions of cytotoxic T cells than high-status females, while the
opposite was observed in males. High-status males had higher
CD20 + /CD3 + ratios than low-status males. Together, our study
identifies the strong age and sex-dependent effects of social adversity
on immune cell proportions in a human-relevant primate model. Thus,
these results provide novel insights into the combined effects of
demography and social adversity on immunity and their potential
contribution to age-related diseases in humans and other animals.
AB - Increasing age is associated with dysregulated immune function and
increased inflammation—patterns that are also observed in individuals
exposed to chronic social adversity. Yet we still know little about how
social adversity impacts the immune system and how it might promote
age-related diseases. Here, we investigated how immune cell diversity
varied with age, sex and social adversity (operationalized as low social
status) in free-ranging rhesus macaques. We found age-related
signatures of immunosenescence, including lower proportions of CD20 + B
cells, CD20 + /CD3 + ratio, and CD4 + /CD8 + T cell ratio – all signs of
diminished antibody production. Age was associated with higher
proportions of CD3 + /CD8 + Cytotoxic T cells, CD16 + /CD3- Natural
Killer cells, CD3 + /CD4 + /CD25 + and CD3 + /CD8 + /CD25 + T cells, and
CD14 + /CD16 + /HLA-DR + intermediate monocytes, and lower levels of
CD14 + /CD16-/HLA-DR + classical monocytes, indicating greater amounts
of inflammation and immune dysregulation. We also found a sex-dependent
effect of exposure to social adversity (i.e., low social status).
High-status males, relative to females, had higher CD20 + /CD3 + ratios
and CD16 + /CD3 Natural Killer cell proportions, and lower proportions
of CD8 + Cytotoxic T cells. Further, low-status females had higher
proportions of cytotoxic T cells than high-status females, while the
opposite was observed in males. High-status males had higher
CD20 + /CD3 + ratios than low-status males. Together, our study
identifies the strong age and sex-dependent effects of social adversity
on immune cell proportions in a human-relevant primate model. Thus,
these results provide novel insights into the combined effects of
demography and social adversity on immunity and their potential
contribution to age-related diseases in humans and other animals.
KW - Age
KW - Inflammation
KW - Sex-differences
KW - Immunosenescence
KW - Social adversity
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828448/
U2 - 10.1007/s11357-023-00962-8
DO - 10.1007/s11357-023-00962-8
M3 - Article
SN - 2509-2723
VL - 46
SP - 2107
EP - 2122
JO - GeroScience
JF - GeroScience
ER -