Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP

Jennifer Amanda Harrison; Ravindranathan K K P Kartha; William Bruce Turnbull; S L  Scheuerl; Jim Naismith; S  Schenkman; Robert Andrew Field

doi:10.1016/S0960-894X(00)00611-9

Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP

Jennifer Amanda Harrison, Ravindranathan K K P Kartha, William Bruce Turnbull, S L Scheuerl, Jim Naismith, S Schenkman, Robert Andrew Field

Research output: Contribution to journal › Article › peer-review

Abstract

NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	141-144
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(00)00611-9
Publication status	Published - Jan 2001

Keywords

HYDROLYSIS

Access to Document

10.1016/S0960-894X(00)00611-9

Cite this

@article{552e53d8c0ff4a5fbe29e0cb97c6e956,

title = "Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP",

abstract = "NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.",

keywords = "HYDROLYSIS",

author = "Harrison, \{Jennifer Amanda\} and Kartha, \{Ravindranathan K K P\} and Turnbull, \{William Bruce\} and Scheuerl, \{S L\} and Jim Naismith and S Schenkman and Field, \{Robert Andrew\}",

year = "2001",

month = jan,

doi = "10.1016/S0960-894X(00)00611-9",

language = "English",

volume = "11",

pages = "141--144",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP

AU - Harrison, Jennifer Amanda

AU - Kartha, Ravindranathan K K P

AU - Turnbull, William Bruce

AU - Scheuerl, S L

AU - Naismith, Jim

AU - Schenkman, S

AU - Field, Robert Andrew

PY - 2001/1

Y1 - 2001/1

N2 - NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.

AB - NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.

KW - HYDROLYSIS

UR - https://www.scopus.com/pages/publications/0035931354

U2 - 10.1016/S0960-894X(00)00611-9

DO - 10.1016/S0960-894X(00)00611-9

M3 - Article

SN - 0960-894X

VL - 11

SP - 141

EP - 144

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this