Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP

Jennifer Amanda Harrison, Ravindranathan K K P Kartha, William Bruce Turnbull, S L Scheuerl, Jim Naismith, S Schenkman, Robert Andrew Field

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume11
Issue number2
DOIs
Publication statusPublished - Jan 2001

Keywords

  • HYDROLYSIS

Fingerprint

Dive into the research topics of 'Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP'. Together they form a unique fingerprint.

Cite this