TY - JOUR
T1 - Hydrolase and sialyltransferase activities of Trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-Gal-beta-O-PNP
AU - Harrison, Jennifer Amanda
AU - Kartha, Ravindranathan K K P
AU - Turnbull, William Bruce
AU - Scheuerl, S L
AU - Naismith, Jim
AU - Schenkman, S
AU - Field, Robert Andrew
PY - 2001/1
Y1 - 2001/1
N2 - NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.
AB - NeuAc-alpha -2,3-Gal-beta -O-PNP has been synthesised and its ability to act as a substrate for the hydrolase and transferase activities of Trypanosoma cruzi trans-sialidase have been investigated. The turn-over of this compound shows marked differences from the behaviour of NeuAc-MU. In addition, distinct differences in the action of T. cruzi trans-sialidase and Clostridium perfringens neuraminidase on NeuAc-alpha -2,3-Gal-beta -O-PNP were apparent. (C) 2001 Elsevier Science Ltd. All rights reserved.
KW - HYDROLYSIS
UR - http://www.scopus.com/inward/record.url?scp=0035931354&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(00)00611-9
DO - 10.1016/S0960-894X(00)00611-9
M3 - Article
SN - 0960-894X
VL - 11
SP - 141
EP - 144
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 2
ER -