Abstract
In the hydrogenation of sluggish unactivated enamine substrates, Rh complexes of electron-deficient phosphines are demonstrated to be far more reactive catalysts than those derived from triphenylphosphine. These operate at low catalyst loadings (down to 0.01 mol %) and are able to reduce tetrasubstituted enamines. The use of the sustainable and environmentally benign solvent (R)-limonene for the reaction is also reported with the amine isolated by acid extraction.
Original language | English |
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Pages (from-to) | 622-627 |
Number of pages | 6 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 11 |
DOIs | |
Publication status | Published - 5 May 2015 |
Keywords
- Alkenes
- Homogeneous catalysis
- Hydrogenation
- Renewable solvents
- Tertiary amines
- Asymmetric hydrogenation
- Enantioselective synthesis
- Functionalized enamines
- Hydroformylation
- Chemistry
- Aldehydes
- Ligands