Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

José Antonio Fuentes García; Ian Carpenter; Nina Kann; Matt  Clarke

doi:10.1039/C3CC45545A

Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

José Antonio Fuentes García, Ian Carpenter, Nina Kann, Matt Clarke

Research output: Contribution to journal › Article › peer-review

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Abstract

Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.

Original language	English
Pages (from-to)	10245-10247
Journal	Chemical Communications
Volume	49
Issue number	87
DOIs	https://doi.org/10.1039/C3CC45545A
Publication status	Published - Sept 2013

Keywords

Iridium complex
Enantioselective hydrogenation
Transfer hydrogenation
Heterocyclic ketones
Cycloalkyl ketones

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10.1039/C3CC45545A

ChemComm2013
Copyright 2013, the Authors. This is an Open Access article licensed under a Creative Commons Attribution 3.0 Unported Licence.
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title = "Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand",

abstract = "Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.",

keywords = "Iridium complex , Enantioselective hydrogenation , Transfer hydrogenation , Heterocyclic ketones , Cycloalkyl ketones ",

author = "{Fuentes Garc{\'i}a}, {Jos{\'e} Antonio} and Ian Carpenter and Nina Kann and Matt Clarke",

year = "2013",

month = sep,

doi = "10.1039/C3CC45545A",

language = "English",

volume = "49",

pages = "10245--10247",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand. / Fuentes García, José Antonio; Carpenter, Ian; Kann, Nina et al.
In: Chemical Communications, Vol. 49, No. 87, 09.2013, p. 10245-10247.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

AU - Fuentes García, José Antonio

AU - Carpenter, Ian

AU - Kann, Nina

AU - Clarke, Matt

PY - 2013/9

Y1 - 2013/9

N2 - Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.

AB - Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.

KW - Iridium complex

KW - Enantioselective hydrogenation

KW - Transfer hydrogenation

KW - Heterocyclic ketones

KW - Cycloalkyl ketones

U2 - 10.1039/C3CC45545A

DO - 10.1039/C3CC45545A

M3 - Article

SN - 1359-7345

VL - 49

SP - 10245

EP - 10247

JO - Chemical Communications

JF - Chemical Communications

IS - 87

ER -

Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

Abstract

Keywords

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