Highly efficient Heck reactions of aryl bromides with n-butyl acrylate mediated by a palladium/phosphine-imidazolium salt system

C L Yang, H M Lee, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

289 Citations (Scopus)

Abstract

A new phosphine-imidazolium salt, L.HBr (1 . HBR = (1-ethylenediphenylphosphino-3-(mesityl))imidazol-2-ylidene), has been prepared, A combination of 0.5 mol % of Pd(dba)(2) and 0.5 mol % of L . HBr in the presence of 2 equiv of Cs2CO3 as base has proven to be highly efficient in the Heck coupling reactions of aryl bromides (from electron deficient to electron-rich aryl bromides) with n-butyl acrylate.

Original languageEnglish
Pages (from-to)1511-1514
Number of pages4
JournalOrganic Letters
Volume3
Issue number10
DOIs
Publication statusPublished - 17 May 2001

Keywords

  • HETEROCYCLIC CARBENE COMPLEXES
  • PALLADIUM/IMIDAZOLIUM CHLORIDE SYSTEM
  • OLEFIN METATHESIS CATALYSTS
  • COUPLING REACTIONS
  • METAL-COMPLEXES
  • PALLADIUM
  • RUTHENIUM
  • HALIDES
  • LIGAND

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