Abstract
We report a new catalytic protocol for the synthesis of γ,δ−unsaturated carbonyl units from simple starting
materials, allylic alcohols and alkynes, via a hydroxalkoxylation/Claisen rearrangement sequence. This new process is more
efficient (higher TON and TOF) and more eco-friendly (increased mass efficiency) than the previous state-of-the-art technique.
In addition, this method tolerates both terminal and internal alkynes. Moreover, computational studies have been carried out in
order to shed light on how the Claisen rearrangement is initiated.
materials, allylic alcohols and alkynes, via a hydroxalkoxylation/Claisen rearrangement sequence. This new process is more
efficient (higher TON and TOF) and more eco-friendly (increased mass efficiency) than the previous state-of-the-art technique.
In addition, this method tolerates both terminal and internal alkynes. Moreover, computational studies have been carried out in
order to shed light on how the Claisen rearrangement is initiated.
| Original language | English |
|---|---|
| Pages (from-to) | 2701-2705 |
| Number of pages | 5 |
| Journal | ACS Catalysis |
| Volume | 4 |
| Early online date | 15 Jul 2014 |
| DOIs | |
| Publication status | Published - 2014 |
Keywords
- gold, hydroalkoxylation, Claisen rearrangement, homoallylic ketones, solvent-free