Abstract
An experimentally simple protocol for the very highly (E)-selective Wadsworth-Emmons reaction [(E):(Z) selectivities in excess of 180:1 in some cases] of a range of straight-chain and branched aliphatic, substituted aromatic, and base-sensitive aldehydes via reaction with an alkyl diethylphosphonoacetate and MeMgBr is reported.
Original language | English |
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Pages (from-to) | 5437-5440 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 10 |
Issue number | 23 |
DOIs | |
Publication status | Published - 4 Dec 2008 |
Keywords
- LATENT ALDEHYDE EQUIVALENTS
- BETA-AMINO ACIDS
- ASYMMETRIC-SYNTHESIS
- ETHYL (DIARYLPHOSPHONO)ACETATES
- OLEFINATION REACTION
- CARBONYL-COMPOUNDS
- ESTERS
- LITHIUM
- CONSTRUCTION
- DERIVATIVES