Highly diastereoselective synthesis of 2,3-dihydro-9bH-thiazolo[2,3-a] isoindolin-5-ones

Steven M. Allin; Darshan G. Vaidya; Michael I. Page; Alexandra M.Z. Slawin

Highly diastereoselective synthesis of 2,3-dihydro-9bH-thiazolo[2,3-a] isoindolin-5-ones

Steven M. Allin^*, Darshan G. Vaidya, Michael I. Page, Alexandra M.Z. Slawin

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Condensation of 2-acetyl benzoic acid with aminothiols proceeds with extremely high diastereoselectivity to produce the desired 2,3-dihydro-9b11- thiazolo[2,3-a]isoindolin-5-one products in good yield. The relative stereochemistry of the major diastereoisomer, formed exclusively when using non-racemic aminothiol substrates, has been determined for the first time by single crystal X-ray analysis.

Original language	English
Pages (from-to)	151-157
Number of pages	7
Journal	ARKIVOC
Volume	2000
Issue number	2 SPEC.ISS.
Publication status	Published - 1 Dec 2000

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title = "Highly diastereoselective synthesis of 2,3-dihydro-9bH-thiazolo[2,3-a] isoindolin-5-ones",

abstract = "Condensation of 2-acetyl benzoic acid with aminothiols proceeds with extremely high diastereoselectivity to produce the desired 2,3-dihydro-9b11- thiazolo[2,3-a]isoindolin-5-one products in good yield. The relative stereochemistry of the major diastereoisomer, formed exclusively when using non-racemic aminothiol substrates, has been determined for the first time by single crystal X-ray analysis.",

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T1 - Highly diastereoselective synthesis of 2,3-dihydro-9bH-thiazolo[2,3-a] isoindolin-5-ones

AU - Allin, Steven M.

AU - Vaidya, Darshan G.

AU - Page, Michael I.

AU - Slawin, Alexandra M.Z.

PY - 2000/12/1

Y1 - 2000/12/1

N2 - Condensation of 2-acetyl benzoic acid with aminothiols proceeds with extremely high diastereoselectivity to produce the desired 2,3-dihydro-9b11- thiazolo[2,3-a]isoindolin-5-one products in good yield. The relative stereochemistry of the major diastereoisomer, formed exclusively when using non-racemic aminothiol substrates, has been determined for the first time by single crystal X-ray analysis.

AB - Condensation of 2-acetyl benzoic acid with aminothiols proceeds with extremely high diastereoselectivity to produce the desired 2,3-dihydro-9b11- thiazolo[2,3-a]isoindolin-5-one products in good yield. The relative stereochemistry of the major diastereoisomer, formed exclusively when using non-racemic aminothiol substrates, has been determined for the first time by single crystal X-ray analysis.

UR - http://www.scopus.com/inward/record.url?scp=0141938804&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0141938804

SN - 1424-6376

VL - 2000

SP - 151

EP - 157

JO - ARKIVOC

JF - ARKIVOC

IS - 2 SPEC.ISS.

ER -

Highly diastereoselective synthesis of 2,3-dihydro-9bH-thiazolo[2,3-a] isoindolin-5-ones

Abstract

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