Highly Active [Pd(μ-Cl)(Cl)(NHC)]2 (NHC = N-Heterocyclic Carbene) in the Cross-Coupling of Grignard Reagents with Aryl Chlorides

Caroline E. Hartmann, Steven Patrick Nolan, Catherine S.J. Cazin

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Cross-coupling reactions of Grignard reagents with functionalized aryl, heteroaryl, and sterically hindered aryl chlorides are reported. A protocol disclosing the coupling of a wide range of substrates using complexes of the type [Pd(mu-Cl)(Cl)(NHC)](2) (NHC = N-heterocyclic carbene) as precatalysts (at low catalyst loading) under mild conditions is presented. The system allows for the synthesis of highly sterically hindered products, including tri- and tetra-ortho-substituted biaryls.

Original languageEnglish
Pages (from-to)2915-2919
Number of pages5
JournalOrganometallics
Volume28
Issue number9
DOIs
Publication statusPublished - 11 May 2009

Keywords

  • RESTRICTED FLEXIBILITY
  • PALLADIUM CATALYSTS
  • KUMADA REACTION
  • BR/MG EXCHANGE
  • BOND FORMATION
  • C-C
  • LIGANDS
  • COMPLEXES
  • ALCOHOLS
  • BROMIDES

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