Heterocellular induction of interferon by negative-sense RNA viruses

S. Chen, J. A. L. Short, D. F. Young, M. J. Killip, M. Schneider, S. Goodbourn, R. E. Randall

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells. (C) 2010 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalVirology
Volume407
Issue number2
DOIs
Publication statusPublished - 25 Nov 2010

Keywords

  • Paramyxovirus
  • Influenza bunyamwera
  • Interferon
  • PARAMYXOVIRUS V-PROTEINS
  • INDUCED ANTIVIRAL STATE
  • RIG-I
  • MONOCLONAL-ANTIBODIES
  • ANTIGENIC DIFFERENCES
  • GENE-EXPRESSION
  • SIMIAN VIRUS-5
  • CELLS
  • BETA
  • ACTIVATION

Fingerprint

Dive into the research topics of 'Heterocellular induction of interferon by negative-sense RNA viruses'. Together they form a unique fingerprint.

Cite this