Heterocellular induction of interferon by negative-sense RNA viruses

S. Chen; J. A. L. Short; D. F. Young; M. J. Killip; M. Schneider; S. Goodbourn; R. E. Randall

doi:10.1016/j.virol.2010.08.008

Heterocellular induction of interferon by negative-sense RNA viruses

S. Chen, J. A. L. Short, D. F. Young, M. J. Killip, M. Schneider, S. Goodbourn, R. E. Randall

Research output: Contribution to journal › Article › peer-review

Abstract

The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells. (C) 2010 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	247-255
Number of pages	9
Journal	Virology
Volume	407
Issue number	2
DOIs	https://doi.org/10.1016/j.virol.2010.08.008
Publication status	Published - 25 Nov 2010

Keywords

Paramyxovirus
Influenza bunyamwera
Interferon
PARAMYXOVIRUS V-PROTEINS
INDUCED ANTIVIRAL STATE
RIG-I
MONOCLONAL-ANTIBODIES
ANTIGENIC DIFFERENCES
GENE-EXPRESSION
SIMIAN VIRUS-5
CELLS
BETA
ACTIVATION

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10.1016/j.virol.2010.08.008

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title = "Heterocellular induction of interferon by negative-sense RNA viruses",

abstract = "The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells. (C) 2010 Elsevier Inc. All rights reserved.",

keywords = "Paramyxovirus, Influenza bunyamwera, Interferon, PARAMYXOVIRUS V-PROTEINS, INDUCED ANTIVIRAL STATE, RIG-I, MONOCLONAL-ANTIBODIES, ANTIGENIC DIFFERENCES, GENE-EXPRESSION, SIMIAN VIRUS-5, CELLS, BETA, ACTIVATION",

author = "S. Chen and Short, {J. A. L.} and Young, {D. F.} and Killip, {M. J.} and M. Schneider and S. Goodbourn and Randall, {R. E.}",

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doi = "10.1016/j.virol.2010.08.008",

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T1 - Heterocellular induction of interferon by negative-sense RNA viruses

AU - Chen, S.

AU - Short, J. A. L.

AU - Young, D. F.

AU - Killip, M. J.

AU - Schneider, M.

AU - Goodbourn, S.

AU - Randall, R. E.

PY - 2010/11/25

Y1 - 2010/11/25

N2 - The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells. (C) 2010 Elsevier Inc. All rights reserved.

AB - The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells. (C) 2010 Elsevier Inc. All rights reserved.

KW - Paramyxovirus

KW - Influenza bunyamwera

KW - Interferon

KW - PARAMYXOVIRUS V-PROTEINS

KW - INDUCED ANTIVIRAL STATE

KW - RIG-I

KW - MONOCLONAL-ANTIBODIES

KW - ANTIGENIC DIFFERENCES

KW - GENE-EXPRESSION

KW - SIMIAN VIRUS-5

KW - CELLS

KW - BETA

KW - ACTIVATION

UR - http://ukpmc.ac.uk/abstract/MED/20833406

U2 - 10.1016/j.virol.2010.08.008

DO - 10.1016/j.virol.2010.08.008

M3 - Article

SN - 0042-6822

VL - 407

SP - 247

EP - 255

JO - Virology

JF - Virology

IS - 2

ER -

Heterocellular induction of interferon by negative-sense RNA viruses

Abstract

Keywords

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