Health economic evaluation of lung cancer screening using a 2 diagnostic blood test: the Early detection of Cancer of the Lung 3 Scotland (ECLS)

Jose Antonio Robles-Zurita, Nicola McMeekin*, Francis Sullivan, Frances S Mair, Andrew Briggs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Background: Diagnostic blood tests have the potential to identify lung cancer in people at high risk. We assessed the cost-effectiveness of a lung cancer screening intervention, using the EarlyCDT®-Lung Test (ECLS) with subsequent X-ray and low-dose chest CT scans (LDCT) for patients with a positive test result, compared to both usual care and LDCT screening for the target population.
Methods: We conducted a model-based lifetime analysis from a UK NHS and personal social services perspective. We estimated incremental net monetary benefit (NMB) for the ECLS intervention compared to no screening and to LDCT screening.
Results: The incremental NMB of ECLS intervention compared to no screening was GBP 33,179 (95% CI: −GBP 81,396, GBP 147,180) and GBP 140,609 (95% CI: -GBP 36,255, GBP 316,612), respectively, for a cost-effectiveness threshold of GBP 20,000 and GBP 30,000 per quality-adjusted life year. The same figures compared with LDCT screening were GBP 162,095 (95% CI: GBP 52,698, GBP 271,735) and GBP 52,185 (95% CI: −GBP 113,152, GBP 220,711).
Conclusions: The ECLS intervention is the most cost-effective screening alternative, with the highest probability of being cost-effective, when compared to no screening or LDCT screening. This result may change with modifications of the parameters, suggesting that the three alternatives considered in the main analysis are potentially cost-effective.
Original languageEnglish
Pages (from-to)3546-3562
Number of pages17
JournalCurrent Oncology
Volume31
Issue number6
DOIs
Publication statusPublished - 18 Jun 2024

Keywords

  • Cost-effectiveness
  • Economic valuation
  • Lung cancer
  • Screening
  • Diagnostic blood test

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