TY - JOUR
T1 - Handheld volumetric manual compression-based quantitative microelastography
AU - Fang, Qi
AU - Frewer, Luke
AU - Zilkens, Renate
AU - Krajancich, Brooke
AU - Curatolo, Andrea
AU - Chin, Lixin
AU - Foo, Ken Y
AU - Lakhiani, Devina D
AU - Sanderson, Rowan W
AU - Wijesinghe, Philip
AU - Anstie, James D
AU - Dessauvagie, Benjamin F
AU - Latham, Bruce
AU - Saunders, Christobel M
AU - Kennedy, Brendan F
N1 - This research was supported by grants and fellowships from the Australian Research Council, the National Health and Medical Research Council (Australia), the National Breast Cancer Foundation (Australia), the Department of Health, Western Australia, the Cancer Council, Western Australia and through a research contract with OncoRes Medical, Australia.
PY - 2020/2/27
Y1 - 2020/2/27
N2 - Compression optical coherence elastography (OCE) typically requires a
mechanical actuator to impart a controlled uniform strain to the sample.
However, for handheld scanning, this adds complexity to the design of
the probe and the actuator stroke limits the amount of strain that can
be applied. In this work, we present a new volumetric imaging approach
that utilizes bidirectional manual compression via the natural motion of
the user's hand to induce strain to the sample, realizing compact,
actuator‐free, handheld compression OCE. In this way, we are able to
demonstrate rapid acquisition of three‐dimensional quantitative
microelastography (QME) datasets of a tissue volume (6 × 6 × 1 mm3)
in 3.4 seconds. We characterize the elasticity sensitivity of this
freehand manual compression approach using a homogeneous silicone
phantom and demonstrate comparable performance to a benchtop mounted,
actuator‐based approach. In addition, we demonstrate handheld volumetric
manual compression‐based QME on a tissue‐mimicking phantom with an
embedded stiff inclusion and on freshly excised human breast specimens
from both mastectomy and wide local excision (WLE) surgeries. Tissue
results are coregistered with postoperative histology, verifying the
capability of our approach to measure the elasticity of tissue and to
distinguish stiff tumor from surrounding soft benign tissue.
AB - Compression optical coherence elastography (OCE) typically requires a
mechanical actuator to impart a controlled uniform strain to the sample.
However, for handheld scanning, this adds complexity to the design of
the probe and the actuator stroke limits the amount of strain that can
be applied. In this work, we present a new volumetric imaging approach
that utilizes bidirectional manual compression via the natural motion of
the user's hand to induce strain to the sample, realizing compact,
actuator‐free, handheld compression OCE. In this way, we are able to
demonstrate rapid acquisition of three‐dimensional quantitative
microelastography (QME) datasets of a tissue volume (6 × 6 × 1 mm3)
in 3.4 seconds. We characterize the elasticity sensitivity of this
freehand manual compression approach using a homogeneous silicone
phantom and demonstrate comparable performance to a benchtop mounted,
actuator‐based approach. In addition, we demonstrate handheld volumetric
manual compression‐based QME on a tissue‐mimicking phantom with an
embedded stiff inclusion and on freshly excised human breast specimens
from both mastectomy and wide local excision (WLE) surgeries. Tissue
results are coregistered with postoperative histology, verifying the
capability of our approach to measure the elasticity of tissue and to
distinguish stiff tumor from surrounding soft benign tissue.
KW - Freehand volumetric imaging
KW - Handheld probe
KW - Optical coherence elastography
KW - Optical coherence tomography
KW - Quantitative micro-elastrogrophy
U2 - 10.1002/jbio.201960196
DO - 10.1002/jbio.201960196
M3 - Article
C2 - 32057188
SN - 1864-063X
VL - Early View
JO - Journal of Biophotonics
JF - Journal of Biophotonics
M1 - e201960196
ER -