Halogenases: structures and functions

Hannes Ludewig; Samuel Molyneux; Scarlet Ferrinho; Kai Guo; Rosemary Lynch; Danai S Gkotsi; Rebecca JM Goss

doi:10.1016/j.sbi.2020.05.012

Halogenases: structures and functions

Hannes Ludewig, Samuel Molyneux, Scarlet Ferrinho, Kai Guo, Rosemary Lynch, Danai S Gkotsi, Rebecca JM Goss

Research output: Contribution to journal › Review article › peer-review

Abstract

Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.

Original language	English
Pages (from-to)	51-60
Number of pages	10
Journal	Current Opinion in Structural Biology
Volume	65
Early online date	30 Jun 2020
DOIs	https://doi.org/10.1016/j.sbi.2020.05.012
Publication status	Published - Dec 2020

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SDG 14 Life Below Water

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10.1016/j.sbi.2020.05.012

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@article{2e63766af50b4a20aa11f551d4d81337,

title = "Halogenases: structures and functions",

abstract = "Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.",

author = "Hannes Ludewig and Samuel Molyneux and Scarlet Ferrinho and Kai Guo and Rosemary Lynch and Gkotsi, \{Danai S\} and Goss, \{Rebecca JM\}",

note = "Funding: ERC GenoChemetics FP7/2007-2013/ERC consolidator grant GCGXC grant agreement no 614779 (RJMG) CSC and EPSRC CRITICAT EP/L016419/1 for studentship support (KG \& SM respectively).",

year = "2020",

month = dec,

doi = "10.1016/j.sbi.2020.05.012",

language = "English",

volume = "65",

pages = "51--60",

journal = "Current Opinion in Structural Biology",

issn = "0959-440X",

publisher = "Elsevier",

}

TY - JOUR

T1 - Halogenases

T2 - structures and functions

AU - Ludewig, Hannes

AU - Molyneux, Samuel

AU - Ferrinho, Scarlet

AU - Guo, Kai

AU - Lynch, Rosemary

AU - Gkotsi, Danai S

AU - Goss, Rebecca JM

N1 - Funding: ERC GenoChemetics FP7/2007-2013/ERC consolidator grant GCGXC grant agreement no 614779 (RJMG) CSC and EPSRC CRITICAT EP/L016419/1 for studentship support (KG & SM respectively).

PY - 2020/12

Y1 - 2020/12

N2 - Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.

AB - Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.

UR - https://www.scopus.com/pages/publications/85087408445

U2 - 10.1016/j.sbi.2020.05.012

DO - 10.1016/j.sbi.2020.05.012

M3 - Review article

SN - 0959-440X

VL - 65

SP - 51

EP - 60

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

ER -

Halogenases: structures and functions

Abstract

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GCGXC: EU FP7 ERC Consolidator Grant 2013 GCGXC

Expanding the GenoChemetic toolbox: radical halogenases and aqueous alkyl halide cross-coupling

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Halogenases: structures and functions

Abstract

UN SDGs

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Projects

GCGXC: EU FP7 ERC Consolidator Grant 2013 GCGXC

Student theses

Expanding the GenoChemetic toolbox: radical halogenases and aqueous alkyl halide cross-coupling

Cite this