Halogenases: structures and functions

Hannes Ludewig, Samuel Molyneux, Scarlet Ferrinho, Kai Guo, Rosemary Lynch, Danai S Gkotsi, Rebecca JM Goss

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.
Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalCurrent Opinion in Structural Biology
Early online date30 Jun 2020
Publication statusPublished - Dec 2020


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