H1 Haemagglutinin receptor complexes

Rupert James Martin Russell; SJ Gamblin; LF Haire; DJ Stevens; B Xiao; Y Ha; JJ Skehel

doi:10.1016/j.ics.2004.01.039

H1 Haemagglutinin receptor complexes

Rupert James Martin Russell, SJ Gamblin, LF Haire, DJ Stevens, B Xiao, Y Ha, JJ Skehel

Research output: Contribution to journal › Article › peer-review

Abstract

An estimated 20 million people died in the influenza pandemic of 1918. The 1918 virus also spread to swine and continues to cause swine influenza outbreaks. We report here the crystal structures of the haemagglutinins (HAs) of the 1918 virus, the first swine influenza virus of 1930, and the human virus of 1934. We also present structures of HAs complexed with receptor analogues that show how human and swine HAs recognise human and avian receptors, and we deduce the receptor-binding properties of the 1918 HA which, in combination with novel antigenicity, contributed to the explosive nature of the 1918 pandemic. (C) 2004 Published by Elsevier B.V.

Original language	English
Pages (from-to)	191-195
Journal	International Congress Series
Volume	1263
DOIs	https://doi.org/10.1016/j.ics.2004.01.039
Publication status	Published - Jun 2004
Event	International Conference on Options for the Control of Influenza V - Okinawa, Japan Duration: 7 Oct 2003 → 11 Oct 2003

Keywords

haemagglutinin
H1
structure
receptor complexes
INFLUENZA-VIRUS HEMAGGLUTININS
1918 SPANISH INFLUENZA
BINDING PROPERTIES
SIALIC-ACID
A-VIRUSES
SPECIFICITY
ORIGIN
H2

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10.1016/j.ics.2004.01.039

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title = "H1 Haemagglutinin receptor complexes",

abstract = "An estimated 20 million people died in the influenza pandemic of 1918. The 1918 virus also spread to swine and continues to cause swine influenza outbreaks. We report here the crystal structures of the haemagglutinins (HAs) of the 1918 virus, the first swine influenza virus of 1930, and the human virus of 1934. We also present structures of HAs complexed with receptor analogues that show how human and swine HAs recognise human and avian receptors, and we deduce the receptor-binding properties of the 1918 HA which, in combination with novel antigenicity, contributed to the explosive nature of the 1918 pandemic. (C) 2004 Published by Elsevier B.V.",

keywords = "haemagglutinin, H1, structure, receptor complexes, INFLUENZA-VIRUS HEMAGGLUTININS, 1918 SPANISH INFLUENZA, BINDING PROPERTIES, SIALIC-ACID, A-VIRUSES, SPECIFICITY, ORIGIN, H2",

author = "Russell, {Rupert James Martin} and SJ Gamblin and LF Haire and DJ Stevens and B Xiao and Y Ha and JJ Skehel",

year = "2004",

month = jun,

doi = "10.1016/j.ics.2004.01.039",

language = "English",

volume = "1263",

pages = "191--195",

journal = "International Congress Series",

publisher = "Elsevier",

note = "International Conference on Options for the Control of Influenza V ; Conference date: 07-10-2003 Through 11-10-2003",

}

TY - JOUR

T1 - H1 Haemagglutinin receptor complexes

AU - Russell, Rupert James Martin

AU - Gamblin, SJ

AU - Haire, LF

AU - Stevens, DJ

AU - Xiao, B

AU - Ha, Y

AU - Skehel, JJ

PY - 2004/6

Y1 - 2004/6

N2 - An estimated 20 million people died in the influenza pandemic of 1918. The 1918 virus also spread to swine and continues to cause swine influenza outbreaks. We report here the crystal structures of the haemagglutinins (HAs) of the 1918 virus, the first swine influenza virus of 1930, and the human virus of 1934. We also present structures of HAs complexed with receptor analogues that show how human and swine HAs recognise human and avian receptors, and we deduce the receptor-binding properties of the 1918 HA which, in combination with novel antigenicity, contributed to the explosive nature of the 1918 pandemic. (C) 2004 Published by Elsevier B.V.

AB - An estimated 20 million people died in the influenza pandemic of 1918. The 1918 virus also spread to swine and continues to cause swine influenza outbreaks. We report here the crystal structures of the haemagglutinins (HAs) of the 1918 virus, the first swine influenza virus of 1930, and the human virus of 1934. We also present structures of HAs complexed with receptor analogues that show how human and swine HAs recognise human and avian receptors, and we deduce the receptor-binding properties of the 1918 HA which, in combination with novel antigenicity, contributed to the explosive nature of the 1918 pandemic. (C) 2004 Published by Elsevier B.V.

KW - haemagglutinin

KW - H1

KW - structure

KW - receptor complexes

KW - INFLUENZA-VIRUS HEMAGGLUTININS

KW - 1918 SPANISH INFLUENZA

KW - BINDING PROPERTIES

KW - SIALIC-ACID

KW - A-VIRUSES

KW - SPECIFICITY

KW - ORIGIN

KW - H2

U2 - 10.1016/j.ics.2004.01.039

DO - 10.1016/j.ics.2004.01.039

M3 - Article

VL - 1263

SP - 191

EP - 195

JO - International Congress Series

JF - International Congress Series

T2 - International Conference on Options for the Control of Influenza V

Y2 - 7 October 2003 through 11 October 2003

ER -

H1 Haemagglutinin receptor complexes

Abstract

Keywords

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