Gold(I)-Mediated C-H Activation of Arenes

Pengfei Lu, Tanya C. Boorman, Alexandra M. Z. Slawin, Igor Larrosa

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)

Abstract

We demonstrate the first Au(I)-mediated C-H activation of arenes. Au(I) salts undergo C-H activation with electron-poor arenes, in stark contrast to Au(III) salts, which activate electron-rich arenes. This operationally simple and highly regioselective process occurs under very mild conditions and gives access to a variety of Au(I)-arene complexes in excellent yields.

Original languageEnglish
Pages (from-to)5580-+
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number16
DOIs
Publication statusPublished - 28 Apr 2010

Keywords

  • ELECTRON-DEFICIENT POLYFLUOROARENES
  • CATALYZED INTRAMOLECULAR ARYLATION
  • PROTON-ABSTRACTION MECHANISM
  • ORGANIC GOLD COMPOUNDS
  • BOND FORMATION
  • ORGANOGOLD CHEMISTRY
  • NONACTIVATED ARENES
  • COUPLING REACTIONS
  • TERMINAL ALKYNES
  • COMPLEXES

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