Gold(I)-catalysed dehydrative formation of ethers from benzylic alcohols and phenols

Richard Marinus Petrus Veenboer, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
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Abstract

We report the cross-dehydrative reaction of two alcohols to form unsymmetrical ethers using NHC-gold(I) complexes (NHC = N-heterocylic carbene). The optimised methodology proceeds under mild reaction conditions and produces water as the sole by-product. The synthetic utility of this environmentally benign methodology is exemplified by forming a range of ethers from readily available phenols bearing electron-withdrawing substituents and secondary benzylic alcohols with various substituents. Finally, the chemoselectivity obtained in these reactions is explained.
Original languageEnglish
Pages (from-to)3819-3825
Number of pages8
JournalGreen Chemistry
Volume17
Issue number7
Early online date8 May 2015
DOIs
Publication statusPublished - 1 Jul 2015

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