Projects per year
Abstract
The improved synthesis of γ-, δ- and ϵ-lactones using a dinuclear N-heterocyclic carbene (NHC)-gold(I) catalyst is reported. This solvent-free process provides access to γ- and δ-lactones in high regio- and stereoselectivity. Reactions were performed at low catalyst loadings and without the need for any additives. The use of a digold pre-catalyst provides a new synthetic route to functionalised ϵ-lactones, poorly accessible using previous methodologies.
Original language | English |
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Pages (from-to) | 3857–3862 |
Journal | Advanced Synthesis & Catalysis |
Volume | 358 |
Issue number | 23 |
Early online date | 23 Nov 2016 |
DOIs | |
Publication status | Published - 7 Dec 2016 |
Keywords
- Gold catalysis
- Lactones
- Low catalyst loading
- N-Heterocyclic carbenes
- Solvent-free conditions
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Dive into the research topics of 'Gold(I)-catalysed cyclisation of alkynoic acids: towards an efficient and eco-friendly synthesis of γ-, δ- and ϵ-lactones'. Together they form a unique fingerprint.Projects
- 1 Finished
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FUNCAT: EU FP7 ERC Advanced Grant - FUNCAT - Fundamental Studies in Organometallic Chemistry and Homogeneous Catalysis
Nolan, S. P. (PI)
1/01/09 → 31/12/14
Project: Standard
Datasets
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Gold(I)-catalysed cyclisation of alkynoic acids: towards an efficient and eco-friendly synthesis of γ-, δ- and ϵ-lactones (dataset)
Gasperini, D. (Creator), Maggi, L. (Creator), Dupuy, S. (Creator), Veenboer, R. (Creator), Cordes, D. B. (Creator), Slawin, A. M. Z. (Creator) & Nolan, S. P. (Creator), Cambridge Crystallographic Data Centre, 2017
https://dx.doi.org/10.5517/ccdc.csd.cc1lcpm8
Dataset