Genome sequence of the metazoan plant-parasitic nematode Meloidogyne incognita

Pierre Abad*, Jerome Gouzy, Jean-Marc Aury, Philippe Castagnone-Sereno, Etienne G. J. Danchin, Emeline Deleury, Laetitia Perfus-Barbeoch, Veronique Anthouard, Francois Artiguenave, Vivian C. Blok, Marie-Cecile Caillaud, Pedro M. Coutinho, Corinne Dasilva, Francesca De Luca, Florence Deau, Magali Esquibet, Timothe Flutre, Jared V. Goldstone, Noureddine Hamamouch, Tarek HeweziOlivier Jaillon, Claire Jubin, Paola Leonetti, Marc Magliano, Tom R. Maier, Gabriel V. Markov, Paul McVeigh, Graziano Pesole, Julie Poulain, Marc Robinson-Rechavi, Erika Sallet, Beatrice Segurens, Delphine Steinbach, Tom Tytgat, Edgardo Ugarte, Cyril van Ghelder, Pasqua Veronico, Thomas J. Baum, Mark Blaxter, Teresa Bleve-Zacheo, Eric L. Davis, Jonathan J. Ewbank, Bruno Favery, Eric Grenier, Bernard Henrissat, John T. Jones, Vincent Laudet, Aaron G. Maule, Hadi Quesneville, Marie-Noelle Rosso, Thomas Schiex, Geert Smant, Jean Weissenbach, Patrick Wincker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

698 Citations (Scopus)

Abstract

Plant-parasitic nematodes are major agricultural pests worldwide and novel approaches to control them are sorely needed. We report the draft genome sequence of the root-knot nematode Meloidogyne incognita, a biotrophic parasite of many crops, including tomato, cotton and coffee. Most of the assembled sequence of this asexually reproducing nematode, totaling 86 Mb, exists in pairs of homologous but divergent segments. This suggests that ancient allelic regions in M. incognita are evolving toward effective haploidy, permitting new mechanisms of adaptation. The number and diversity of plant cell wall-degrading enzymes in M. incognita is unprecedented in any animal for which a genome sequence is available, and may derive from multiple horizontal gene transfers from bacterial sources. Our results provide insights into the adaptations required by metazoans to successfully parasitize immunocompetent plants, and open the way for discovering new antiparasitic strategies.

Original languageEnglish
Pages (from-to)909-915
Number of pages7
JournalNature Biotechnology
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 2008

Keywords

  • ROOT-KNOT NEMATODES
  • CAENORHABDITIS-ELEGANS
  • PHYTOPATHOGENIC BACTERIA
  • BDELLOID ROTIFERS
  • GENES
  • PROTEIN
  • CLONING
  • IDENTIFICATION
  • EXPRESSION
  • PREDICTION

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