Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors

Simon Heilbronner, Matthew T. G. Holden, Andries van Tonder, Joan A. Geoghegan, Timothy J. Foster*, Julian Parkhill, Stephen D. Bentley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Staphylococcus lugdunensis is an opportunistic pathogen related to Staphylococcus aureus and Staphylococcus epidermidis. The genome sequence of S. lugdunensis strain N920143 has been compared with other staphylococci, and genes were identified that could promote survival of S. lugdunensis on human skin and pathogenesis of infections. Staphylococcus lugdunensis lacks virulence factors that characterize S. aureus and harbours a smaller number of genes encoding surface proteins. It is the only staphylococcal species other than S. aureus that possesses a locus encoding iron-regulated surface determinant (Isd) proteins involved in iron acquisition from haemoglobin.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalFEMS Microbiology Letters
Volume322
Issue number1
DOIs
Publication statusPublished - Sept 2011

Keywords

  • Staphylococcus lugdunensis
  • genome sequence
  • surface proteins
  • virulence factors
  • GENUS STAPHYLOCOCCUS
  • AUREUS
  • PROTEIN
  • RESISTANCE
  • BINDING
  • ISDA
  • PATHOGENESIS
  • EPIDERMIDIS
  • FIBRINOGEN
  • DEFENSINS

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