Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors

Simon Heilbronner; Matthew T. G. Holden; Andries van Tonder; Joan A. Geoghegan; Timothy J. Foster; Julian Parkhill; Stephen D. Bentley

doi:10.1111/j.1574-6968.2011.02339.x

Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors

Simon Heilbronner, Matthew T. G. Holden, Andries van Tonder, Joan A. Geoghegan, Timothy J. Foster^*, Julian Parkhill, Stephen D. Bentley

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Staphylococcus lugdunensis is an opportunistic pathogen related to Staphylococcus aureus and Staphylococcus epidermidis. The genome sequence of S. lugdunensis strain N920143 has been compared with other staphylococci, and genes were identified that could promote survival of S. lugdunensis on human skin and pathogenesis of infections. Staphylococcus lugdunensis lacks virulence factors that characterize S. aureus and harbours a smaller number of genes encoding surface proteins. It is the only staphylococcal species other than S. aureus that possesses a locus encoding iron-regulated surface determinant (Isd) proteins involved in iron acquisition from haemoglobin.

Original language	English
Pages (from-to)	60-67
Number of pages	8
Journal	FEMS Microbiology Letters
Volume	322
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2011.02339.x
Publication status	Published - Sept 2011

Keywords

Staphylococcus lugdunensis
genome sequence
surface proteins
virulence factors
GENUS STAPHYLOCOCCUS
AUREUS
PROTEIN
RESISTANCE
BINDING
ISDA
PATHOGENESIS
EPIDERMIDIS
FIBRINOGEN
DEFENSINS

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10.1111/j.1574-6968.2011.02339.x

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title = "Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors",

abstract = "Staphylococcus lugdunensis is an opportunistic pathogen related to Staphylococcus aureus and Staphylococcus epidermidis. The genome sequence of S. lugdunensis strain N920143 has been compared with other staphylococci, and genes were identified that could promote survival of S. lugdunensis on human skin and pathogenesis of infections. Staphylococcus lugdunensis lacks virulence factors that characterize S. aureus and harbours a smaller number of genes encoding surface proteins. It is the only staphylococcal species other than S. aureus that possesses a locus encoding iron-regulated surface determinant (Isd) proteins involved in iron acquisition from haemoglobin.",

keywords = "Staphylococcus lugdunensis, genome sequence, surface proteins, virulence factors, GENUS STAPHYLOCOCCUS, AUREUS, PROTEIN, RESISTANCE, BINDING, ISDA, PATHOGENESIS, EPIDERMIDIS, FIBRINOGEN, DEFENSINS",

author = "Simon Heilbronner and Holden, {Matthew T. G.} and {van Tonder}, Andries and Geoghegan, {Joan A.} and Foster, {Timothy J.} and Julian Parkhill and Bentley, {Stephen D.}",

year = "2011",

month = sep,

doi = "10.1111/j.1574-6968.2011.02339.x",

language = "English",

volume = "322",

pages = "60--67",

journal = "FEMS Microbiology Letters",

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T1 - Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors

AU - Heilbronner, Simon

AU - Holden, Matthew T. G.

AU - van Tonder, Andries

AU - Geoghegan, Joan A.

AU - Foster, Timothy J.

AU - Parkhill, Julian

AU - Bentley, Stephen D.

PY - 2011/9

Y1 - 2011/9

N2 - Staphylococcus lugdunensis is an opportunistic pathogen related to Staphylococcus aureus and Staphylococcus epidermidis. The genome sequence of S. lugdunensis strain N920143 has been compared with other staphylococci, and genes were identified that could promote survival of S. lugdunensis on human skin and pathogenesis of infections. Staphylococcus lugdunensis lacks virulence factors that characterize S. aureus and harbours a smaller number of genes encoding surface proteins. It is the only staphylococcal species other than S. aureus that possesses a locus encoding iron-regulated surface determinant (Isd) proteins involved in iron acquisition from haemoglobin.

AB - Staphylococcus lugdunensis is an opportunistic pathogen related to Staphylococcus aureus and Staphylococcus epidermidis. The genome sequence of S. lugdunensis strain N920143 has been compared with other staphylococci, and genes were identified that could promote survival of S. lugdunensis on human skin and pathogenesis of infections. Staphylococcus lugdunensis lacks virulence factors that characterize S. aureus and harbours a smaller number of genes encoding surface proteins. It is the only staphylococcal species other than S. aureus that possesses a locus encoding iron-regulated surface determinant (Isd) proteins involved in iron acquisition from haemoglobin.

KW - Staphylococcus lugdunensis

KW - genome sequence

KW - surface proteins

KW - virulence factors

KW - GENUS STAPHYLOCOCCUS

KW - AUREUS

KW - PROTEIN

KW - RESISTANCE

KW - BINDING

KW - ISDA

KW - PATHOGENESIS

KW - EPIDERMIDIS

KW - FIBRINOGEN

KW - DEFENSINS

U2 - 10.1111/j.1574-6968.2011.02339.x

DO - 10.1111/j.1574-6968.2011.02339.x

M3 - Article

SN - 0378-1097

VL - 322

SP - 60

EP - 67

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 1

ER -

Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors

Abstract

Keywords

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