Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW)

Matthew T. G. Holden*, Jodi A. Lindsay, Craig Corton, Michael A. Quail, Joshua D. Cockfield, Smriti Pathak, Rahul Batra, Julian Parkhill, Stephen D. Bentley, Jonathan D. Edgeworth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

156 Citations (Scopus)
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Abstract

The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions ( 635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.

Original languageEnglish
Pages (from-to)888-892
Number of pages5
JournalJournal of Bacteriology
Volume192
Issue number3
Early online date30 Nov 2009
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Nucleotide-sequence
  • Evolution
  • Strain
  • Identification
  • Epidermidis
  • Virulence
  • Proteins
  • Clone
  • Gene
  • Chromosome

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