Genetics of human handedness

Silvia Paracchini

doi:10.1007/978-1-0716-4240-5_18

Genetics of human handedness

Silvia Paracchini

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Around the world, about 10% of people prefer using their left hand. Handedness exhibits a consistent but modest (~25%) genetic component as reported across independent studies. Advances in genomic technologies combined with very large samples have led to the identification of specific genes associated with handedness. Most of these genes have a clear role in neurodevelopment, and the results provide evidence for shared biology contributing to handedness, cerebral asymmetries, and psychiatric disorders. It has become clear that human handedness is highly polygenic, and no individual gene is expected to play a major role. This chapter illustrates the methodology used in genomic studies and the implications of the most recent findings.

Original language	English
Title of host publication	Lateralized brain functions
Subtitle of host publication	methods in human and non-human species
Editors	Lesley J. Rogers, Giorgio Vallortigara
Place of Publication	New York, NY
Publisher	Humana Press
Chapter	18
Pages	641-663
Number of pages	23
Edition	2nd
ISBN (Electronic)	9781071642405
ISBN (Print)	9781071642399, 9781071642429
DOIs	https://doi.org/10.1007/978-1-0716-4240-5_18
Publication status	Published - 13 Dec 2024

Publication series

Name	Neuromethods
Volume	217
ISSN (Print)	0893-2336
ISSN (Electronic)	1940-6045

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Association studies
Complex trait genetics
GWAS
Handedness
Rare variants

Access to Document

10.1007/978-1-0716-4240-5_18

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title = "Genetics of human handedness",

abstract = "Around the world, about 10\% of people prefer using their left hand. Handedness exhibits a consistent but modest (\textasciitilde{}25\%) genetic component as reported across independent studies. Advances in genomic technologies combined with very large samples have led to the identification of specific genes associated with handedness. Most of these genes have a clear role in neurodevelopment, and the results provide evidence for shared biology contributing to handedness, cerebral asymmetries, and psychiatric disorders. It has become clear that human handedness is highly polygenic, and no individual gene is expected to play a major role. This chapter illustrates the methodology used in genomic studies and the implications of the most recent findings.",

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KW - GWAS

KW - Handedness

KW - Rare variants

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A2 - Vallortigara, Giorgio

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ER -

Genetics of human handedness

Abstract

Publication series

UN SDGs

Keywords

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Handle.net

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