Genetic reassortment amoung recently circulating human influenza A and B viruses

YP Lin, V Gregory, M Bennett, H Wright, P Boyd-Kirkup, Rupert James Martin Russell, AJ Hay

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Evolution of influenza viruses involves both the gradual accumulation of mutations and genetic reassortment, due to the segmented nature of the RNA genome. Co-circulation of H1N1 and H3N2 viruses since 1977 provided the opportunity for reassortment between the subtypes. Although various reassortant viruses have circulated to limited extents, not until 2002 did H1N2 viruses, deriving an H1 from H1N1 viruses and seven genes from contemporary H3N2 viruses, become established worldwide. Following the re-emergence of B/Victoria/2/87-lineage viruses during 2001 2002, reassortants possessing a B/Victoria-lineage HA and B/Yamagata-lineage NA became the predominant B viruses circulating since the latter part of 2002. As well as demonstrating the role of reassortment in antigenic and genetic variation, these events provide further evidence of the limited divergence in the functional characteristics of HA and NA of distinct subtypes or lineages during the evolution of human influenza viruses. (C) 2003 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)178-193
JournalInternational Congress Series
Volume1263
DOIs
Publication statusPublished - Jun 2004
EventInternational Conference on Options for the Control of Influenza V - Okinawa, Japan
Duration: 7 Oct 200311 Oct 2003

Keywords

  • influenza A
  • influenza B
  • genetic reassortment
  • EVOLUTION
  • SEASON

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