Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids

Rebecca J. M. Goss*, Simon E. Lanceron, Nicola J. Wise, Steven J. Moss

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the precursor-directed biosynthesis of rapamycin.

Original languageEnglish
Pages (from-to)4071-4073
Number of pages3
JournalOrganic & Biomolecular Chemistry
Volume4
Issue number22
DOIs
Publication statusPublished - 2006

Keywords

  • UNIT

Fingerprint

Dive into the research topics of 'Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids'. Together they form a unique fingerprint.

Cite this