General and efficient methodology for the Suzuki-Miyaura reaction in technical grade 2-propanol

O Navarro, Y Oonishi, R A Kelly, E D Stevens, O Briel, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

The reaction. profile of a series of palladium-based catalysts was examined in the Suzuki-Miyaura reaction using technical grade 2-propanol as solvent and potassium t-butoxide as base. The results generally show high activity. The method allows for the coupling of electron-rich aryl chlorides with sterically hindered aryl boronic acids to produce tri-ortho-substituted biaryls in high yields using very mild conditions and short reaction times. (C) 2004 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)3722-3727
Number of pages6
JournalJournal of Organometallic Chemistry
Volume689
Issue number23
DOIs
Publication statusPublished - 15 Nov 2004

Keywords

  • Suzuki-Miyaura reaction
  • palladium
  • catalysis
  • N-heterocyclic carbene
  • CROSS-COUPLING REACTIONS
  • HINDERED ARYL CHLORIDES
  • ROOM-TEMPERATURE
  • ORGANOBORON COMPOUNDS
  • BORONIC ACIDS
  • COMPLEXES
  • ACTIVATION
  • CATALYSTS
  • BROMIDES
  • BIARYLS

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