General and efficient catalytic amination of aryl chlorides using a palladium/bulky nucleophilic carbene system

J  Huang; G  Grasa; Steven Patrick Nolan

General and efficient catalytic amination of aryl chlorides using a palladium/bulky nucleophilic carbene system

J Huang, G Grasa, Steven Patrick Nolan

Research output: Contribution to journal › Article › peer-review

Abstract

[GRAPHICS]

A combination of palladium and an imidazolium chloride has been used as catalyst precursor in the amination of aryl chlorides. The imidazolium salt IPrHCl (4, IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) was found to provide the most efficient transformation rates in this catalytic system. This new system proves general and efficient for aryl chlorides as well as aryl bromides and iodides.

Original language	English
Pages (from-to)	1307-1309
Number of pages	3
Journal	Organic Letters
Volume	1
Issue number	8
Publication status	Published - 21 Oct 1999

Keywords

TRANSITION-METAL COMPLEXES
N-HETEROCYCLIC CARBENES
CROSS-COUPLING REACTION
HOMOGENEOUS CATALYSIS
ARYLBORONIC ACIDS
CHLOROARENES
HALIDES
BIARYLS

Cite this

@article{4ac73ddd725d4eab88dc28ab3e81186f,

title = "General and efficient catalytic amination of aryl chlorides using a palladium/bulky nucleophilic carbene system",

abstract = "[GRAPHICS]A combination of palladium and an imidazolium chloride has been used as catalyst precursor in the amination of aryl chlorides. The imidazolium salt IPrHCl (4, IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) was found to provide the most efficient transformation rates in this catalytic system. This new system proves general and efficient for aryl chlorides as well as aryl bromides and iodides.",

keywords = "TRANSITION-METAL COMPLEXES, N-HETEROCYCLIC CARBENES, CROSS-COUPLING REACTION, HOMOGENEOUS CATALYSIS, ARYLBORONIC ACIDS, CHLOROARENES, HALIDES, BIARYLS",

author = "J Huang and G Grasa and Nolan, \{Steven Patrick\}",

year = "1999",

month = oct,

day = "21",

language = "English",

volume = "1",

pages = "1307--1309",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society (ACS)",

number = "8",

}

TY - JOUR

T1 - General and efficient catalytic amination of aryl chlorides using a palladium/bulky nucleophilic carbene system

AU - Huang, J

AU - Grasa, G

AU - Nolan, Steven Patrick

PY - 1999/10/21

Y1 - 1999/10/21

N2 - [GRAPHICS]A combination of palladium and an imidazolium chloride has been used as catalyst precursor in the amination of aryl chlorides. The imidazolium salt IPrHCl (4, IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) was found to provide the most efficient transformation rates in this catalytic system. This new system proves general and efficient for aryl chlorides as well as aryl bromides and iodides.

AB - [GRAPHICS]A combination of palladium and an imidazolium chloride has been used as catalyst precursor in the amination of aryl chlorides. The imidazolium salt IPrHCl (4, IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) was found to provide the most efficient transformation rates in this catalytic system. This new system proves general and efficient for aryl chlorides as well as aryl bromides and iodides.

KW - TRANSITION-METAL COMPLEXES

KW - N-HETEROCYCLIC CARBENES

KW - CROSS-COUPLING REACTION

KW - HOMOGENEOUS CATALYSIS

KW - ARYLBORONIC ACIDS

KW - CHLOROARENES

KW - HALIDES

KW - BIARYLS

UR - https://www.scopus.com/pages/publications/0001152076

M3 - Article

SN - 1523-7060

VL - 1

SP - 1307

EP - 1309

JO - Organic Letters

JF - Organic Letters

IS - 8

ER -

General and efficient catalytic amination of aryl chlorides using a palladium/bulky nucleophilic carbene system

Abstract

Keywords

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