General and efficient catalytic amination of aryl chlorides using a palladium/bulky nucleophilic carbene system

J Huang, G Grasa, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

247 Citations (Scopus)

Abstract

[GRAPHICS]

A combination of palladium and an imidazolium chloride has been used as catalyst precursor in the amination of aryl chlorides. The imidazolium salt IPrHCl (4, IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) was found to provide the most efficient transformation rates in this catalytic system. This new system proves general and efficient for aryl chlorides as well as aryl bromides and iodides.

Original languageEnglish
Pages (from-to)1307-1309
Number of pages3
JournalOrganic Letters
Volume1
Issue number8
Publication statusPublished - 21 Oct 1999

Keywords

  • TRANSITION-METAL COMPLEXES
  • N-HETEROCYCLIC CARBENES
  • CROSS-COUPLING REACTION
  • HOMOGENEOUS CATALYSIS
  • ARYLBORONIC ACIDS
  • CHLOROARENES
  • HALIDES
  • BIARYLS

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