Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications

Sharon T. Gregg; Qingchun Yuan; Russell E. Morris; Bo Xiao

doi:10.1016/j.mtcomm.2017.07.007

Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications

Sharon T. Gregg, Qingchun Yuan, Russell E. Morris, Bo Xiao

Research output: Contribution to journal › Article › peer-review

Abstract

It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

Original language	English
Pages (from-to)	95-105
Journal	Materials Today Communications
Volume	12
Early online date	31 Jul 2017
DOIs	https://doi.org/10.1016/j.mtcomm.2017.07.007
Publication status	Published - Sept 2017

Keywords

Nitric oxide
Drug delivery
Zeolite
Metal organic framework
Nitric oxide biological function
Antomicrobials

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10.1016/j.mtcomm.2017.07.007

Morris_2017_MTC_Bio-functionalisedSolids_AAM
© 2017 Elsevier Ltd. All rights reserved. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.mtcomm.2017.07.007
Accepted author manuscript, 1.23 MBLicence: CC BY-NC-ND

Cite this

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title = "Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications",

abstract = "It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.",

keywords = "Nitric oxide, Drug delivery, Zeolite, Metal organic framework, Nitric oxide biological function, Antomicrobials",

author = "Gregg, {Sharon T.} and Qingchun Yuan and Morris, {Russell E.} and Bo Xiao",

note = "The authors gratefully appreciate the supports from EPSRC (EP/M027295/1), the initial research funding from Queen{\textquoteright}s University Belfast and Aston University, and the DEL PhD studentship.",

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doi = "10.1016/j.mtcomm.2017.07.007",

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AU - Gregg, Sharon T.

AU - Yuan, Qingchun

AU - Morris, Russell E.

AU - Xiao, Bo

N1 - The authors gratefully appreciate the supports from EPSRC (EP/M027295/1), the initial research funding from Queen’s University Belfast and Aston University, and the DEL PhD studentship.

PY - 2017/9

Y1 - 2017/9

N2 - It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

AB - It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

KW - Nitric oxide

KW - Drug delivery

KW - Zeolite

KW - Metal organic framework

KW - Nitric oxide biological function

KW - Antomicrobials

U2 - 10.1016/j.mtcomm.2017.07.007

DO - 10.1016/j.mtcomm.2017.07.007

M3 - Article

SN - 2352-4928

VL - 12

SP - 95

EP - 105

JO - Materials Today Communications

JF - Materials Today Communications

ER -

Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications

Abstract

Keywords

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