FRIENDLY Regulates Mitochondrial Distribution, Fusion, and Quality Control in Arabidopsis

Amr M. El Zawily, Markus Schwarzlaender, Iris Finkemeier, Iain G. Johnston, Abdelilah Benamar, Yongguo Cao, Clemence Gissot, Andreas J. Meyer, Ken Wilson, Raju Datla, David Macherel, Nick S. Jones, David C. Logan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

Mitochondria are defining components of most eukaryotes. However, higher plant mitochondria differ biochemically, morphologically, and dynamically from those in other eukaryotes. FRIENDLY, a member of the CLUSTERED MITOCHONDRIA superfamily, is conserved among eukaryotes and is required for correct distribution of mitochondria within the cell. We sought to understand how disruption of FRIENDLY function in Arabidopsis (Arabidopsis thaliana) leads to mitochondrial clustering and the effects of this aberrant chondriome on cell and whole-plant physiology. We present evidence for a role of FRIENDLY in mediating intermitochondrial association, which is a necessary prelude to mitochondrial fusion. We demonstrate that disruption of mitochondrial association, motility, and chondriome structure in friendly affects mitochondrial quality control and leads to mitochondrial stress, cell death, and strong growth phenotypes.

Original languageEnglish
Pages (from-to)808-U517
Number of pages28
JournalPlant Physiology
Volume166
Issue number2
DOIs
Publication statusPublished - Oct 2014

Keywords

  • NAC TRANSCRIPTION FACTORS
  • DOMINANT OPTIC ATROPHY
  • SUBSEQUENT CELL-DEATH
  • CHLOROPHYLL FLUORESCENCE
  • STRESS-RESPONSE
  • PLANT-CELLS
  • SUBCELLULAR-LOCALIZATION
  • FUNCTIONAL-ANALYSIS
  • MEMBRANE DYNAMICS
  • OXIDATIVE STRESS

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