Friend or enemy?: Review of 17β‐HSD10 and its role in human health or disease

Lucie Vinklarova; Monika Schmidt; Ondrej Benek; Kamil Kuca; Frank Gunn-Moore; Kamil Musilek

doi:10.1111/jnc.15027

Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease

Lucie Vinklarova, Monika Schmidt, Ondrej Benek, Kamil Kuca, Frank Gunn-Moore, Kamil Musilek

Research output: Contribution to journal › Review article › peer-review

Abstract

17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer’s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.

Original language	English
Journal	Journal of Neurochemistry
Volume	Early view
Early online date	23 May 2020
DOIs	https://doi.org/10.1111/jnc.15027
Publication status	E-pub ahead of print - 23 May 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

17β-hydroxysteroid dehydrogenase type 10
Alzheimer’s disease
Cancer
Estradiol
HSD10
Neurosteroid

Access to Document

10.1111/jnc.15027

Gunn-Moore_2020_JofNeur_Friendoreneny_AAM
© 2020 International Society for Neurochemistry. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1111/jnc.15027
Accepted author manuscript, 22.4 MB

Cite this

@article{d1b52d5a4c8b4d5b867e4a8382722d26,

title = "Friend or enemy?: Review of 17β‐HSD10 and its role in human health or disease",

abstract = "17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer{\textquoteright}s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.",

keywords = "17β-hydroxysteroid dehydrogenase type 10, Alzheimer{\textquoteright}s disease, Cancer, Estradiol, HSD10, Neurosteroid",

author = "Lucie Vinklarova and Monika Schmidt and Ondrej Benek and Kamil Kuca and Frank Gunn-Moore and Kamil Musilek",

note = "Funding: Ministry of Health of the Czech Republic (no. NV19-09-00578), Ministry of Education, Youth and Sports of the Czech Republic (project ESF no. CZ.02.1.01/0.0/0.0/18\_069/0010054), University of Hradec Kralove (Faculty of Science, no. VT2019-2021, SV2113-2019, and Postdoctoral job positions at UHK), Wellcome Trust (204821/Z/16/Z), The Rosetrees Trust and the RS MacDonald Charitable Trust.",

year = "2020",

month = may,

day = "23",

doi = "10.1111/jnc.15027",

language = "English",

volume = "Early view",

journal = "Journal of Neurochemistry",

issn = "0022-3042",

publisher = "John Wiley \& Sons, Ltd",

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T2 - Review of 17β‐HSD10 and its role in human health or disease

AU - Vinklarova, Lucie

AU - Schmidt, Monika

AU - Benek, Ondrej

AU - Kuca, Kamil

AU - Gunn-Moore, Frank

AU - Musilek, Kamil

N1 - Funding: Ministry of Health of the Czech Republic (no. NV19-09-00578), Ministry of Education, Youth and Sports of the Czech Republic (project ESF no. CZ.02.1.01/0.0/0.0/18_069/0010054), University of Hradec Kralove (Faculty of Science, no. VT2019-2021, SV2113-2019, and Postdoctoral job positions at UHK), Wellcome Trust (204821/Z/16/Z), The Rosetrees Trust and the RS MacDonald Charitable Trust.

PY - 2020/5/23

Y1 - 2020/5/23

N2 - 17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer’s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.

AB - 17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β‐HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer’s disease (AD), and in hormone dependent cancer. The objective of this review is to provide a summary about physiological functions and pathological roles of 17β‐HSD10 and the modulators of its activity.

KW - 17β-hydroxysteroid dehydrogenase type 10

KW - Alzheimer’s disease

KW - Cancer

KW - Estradiol

KW - HSD10

KW - Neurosteroid

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SN - 0022-3042

VL - Early view

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JF - Journal of Neurochemistry

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