Abstract
17β‐hydroxysteroid dehydrogenase (17β‐HSD10) is a multifunctional human
enzyme with important roles both as a structural component and also as a
catalyst of many metabolic pathways. This mitochondrial enzyme has
important functions in the metabolism, development and aging of the
neural system, where it is involved in the homeostasis of neurosteroids,
especially in regard to estradiol, changes in which make it an
essential part of neurodegenerative pathology. These roles therefore,
indicate that 17β‐HSD10 may be a possible druggable target for
neurodegenerative diseases including Alzheimer’s disease (AD), and in
hormone dependent cancer. The objective of this review is to provide a
summary about physiological functions and pathological roles of
17β‐HSD10 and the modulators of its activity.
| Original language | English |
|---|---|
| Journal | Journal of Neurochemistry |
| Volume | Early view |
| Early online date | 23 May 2020 |
| DOIs | |
| Publication status | E-pub ahead of print - 23 May 2020 |
Keywords
- 17β-hydroxysteroid dehydrogenase type 10
- Alzheimer’s disease
- Cancer
- Estradiol
- HSD10
- Neurosteroid
Access to Document
- Gunn-Moore_2020_JofNeur_Friendoreneny_AAM
© 2020 International Society for Neurochemistry. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1111/jnc.15027