FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways

Paolo Devanna, Jeroen Middelbeek, Sonja C Vernes

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

FOXP2 was the first gene shown to cause a Mendelian form of speech and language disorder. Although developmentally expressed in many organs, loss of a single copy of FOXP2 leads to a phenotype that is largely restricted to orofacial impairment during articulation and linguistic processing deficits. Why perturbed FOXP2 function affects specific aspects of the developing brain remains elusive. We investigated the role of FOXP2 in neuronal differentiation and found that FOXP2 drives molecular changes consistent with neuronal differentiation in a human model system. We identified a network of FOXP2 regulated genes related to retinoic acid signaling and neuronal differentiation. FOXP2 also produced phenotypic changes associated with neuronal differentiation including increased neurite outgrowth and reduced migration. Crucially, cells expressing FOXP2 displayed increased sensitivity to retinoic acid exposure. This suggests a mechanism by which FOXP2 may be able to increase the cellular differentiation response to environmental retinoic acid cues for specific subsets of neurons in the brain. These data demonstrate that FOXP2 promotes neuronal differentiation by interacting with the retinoic acid signaling pathway and regulates key processes required for normal circuit formation such as neuronal migration and neurite outgrowth. In this way, FOXP2, which is found only in specific subpopulations of neurons in the brain, may drive precise neuronal differentiation patterns and/or control localization and connectivity of these FOXP2 positive cells.

Original languageEnglish
Pages (from-to)305
JournalFrontiers in Cellular Neuroscience
Volume8
DOIs
Publication statusPublished - 2014

Fingerprint

Dive into the research topics of 'FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways'. Together they form a unique fingerprint.

Cite this