Formal synthesis of (+)-lactacystin from L-serine

Philip C. Bulman Page; Ross L. Goodyear; Yohan Chan; Alexandra M. Z. Slawin; Steven M. Allin

doi:10.1039/c9ra07244f

Formal synthesis of (+)-lactacystin from L-serine

Philip C. Bulman Page^*, Ross L. Goodyear, Yohan Chan, Alexandra M. Z. Slawin, Steven M. Allin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

Original language	English
Pages (from-to)	30019-30032
Number of pages	14
Journal	RSC Advances
Volume	9
Issue number	51
Early online date	24 Sept 2019
DOIs	https://doi.org/10.1039/c9ra07244f
Publication status	E-pub ahead of print - 24 Sept 2019

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10.1039/c9ra07244fLicence: CC BY

BulmanPage_2019_RSCAdv_Formal_CC
Copyright © 2019 The Author(s). Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Final published version, 1.14 MBLicence: CC BY

Cite this

@article{91f2b42266fe484097a194511e5464a9,

title = "Formal synthesis of (+)-lactacystin from L-serine",

abstract = "A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.",

author = "Page, \{Philip C. Bulman\} and Goodyear, \{Ross L.\} and Yohan Chan and Slawin, \{Alexandra M. Z.\} and Allin, \{Steven M.\}",

note = "This investigation has enjoyed the support of Charnwood Molecular Ltd and the University of East Anglia.",

year = "2019",

month = sep,

day = "24",

doi = "10.1039/c9ra07244f",

language = "English",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Formal synthesis of (+)-lactacystin from L-serine

AU - Page, Philip C. Bulman

AU - Goodyear, Ross L.

AU - Chan, Yohan

AU - Slawin, Alexandra M. Z.

AU - Allin, Steven M.

N1 - This investigation has enjoyed the support of Charnwood Molecular Ltd and the University of East Anglia.

PY - 2019/9/24

Y1 - 2019/9/24

N2 - A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

AB - A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

UR - https://www.scopus.com/pages/publications/85072662372

U2 - 10.1039/c9ra07244f

DO - 10.1039/c9ra07244f

M3 - Article

SN - 2046-2069

VL - 9

SP - 30019

EP - 30032

JO - RSC Advances

JF - RSC Advances

IS - 51

ER -

Formal synthesis of (+)-lactacystin from L-serine

Abstract

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