Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport

Stefano Bresciani; Tomas Lebl; Alexandra M. Z. Slawin; David O'Hagan

doi:10.1039/c0cc01128b

Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport

Stefano Bresciani, Tomas Lebl, Alexandra M. Z. Slawin, David O'Hagan

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose were prepared and characterised and these novel sugar analogues were explored by 2D-F-19-EXSY NMR for their potential to cross erythrocyte (red blood cell) membranes, by comparison with the well known capacity of erythrocytes to transport D-glucose.

Original language	English
Pages (from-to)	5434-5436
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	30
DOIs	https://doi.org/10.1039/c0cc01128b
Publication status	Published - 2010

Keywords

SUGARS
ALCOHOL
PROBES

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10.1039/c0cc01128b

Synthesis and properties of novel sequen: Synthesis and properties of novel sequentially fluorinated motifs in organcic chemistry
O'Hagan, D. (PI)
EPSRC
24/03/08 → 23/03/11
Project: Standard

Cite this

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title = "Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport",

abstract = "The 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose were prepared and characterised and these novel sugar analogues were explored by 2D-F-19-EXSY NMR for their potential to cross erythrocyte (red blood cell) membranes, by comparison with the well known capacity of erythrocytes to transport D-glucose.",

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author = "Stefano Bresciani and Tomas Lebl and Slawin, {Alexandra M. Z.} and David O'Hagan",

year = "2010",

doi = "10.1039/c0cc01128b",

language = "English",

volume = "46",

pages = "5434--5436",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "30",

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T1 - Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport

AU - Bresciani, Stefano

AU - Lebl, Tomas

AU - Slawin, Alexandra M. Z.

AU - O'Hagan, David

PY - 2010

Y1 - 2010

N2 - The 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose were prepared and characterised and these novel sugar analogues were explored by 2D-F-19-EXSY NMR for their potential to cross erythrocyte (red blood cell) membranes, by comparison with the well known capacity of erythrocytes to transport D-glucose.

AB - The 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose were prepared and characterised and these novel sugar analogues were explored by 2D-F-19-EXSY NMR for their potential to cross erythrocyte (red blood cell) membranes, by comparison with the well known capacity of erythrocytes to transport D-glucose.

KW - SUGARS

KW - ALCOHOL

KW - PROBES

U2 - 10.1039/c0cc01128b

DO - 10.1039/c0cc01128b

M3 - Article

SN - 1359-7345

VL - 46

SP - 5434

EP - 5436

JO - Chemical Communications

JF - Chemical Communications

IS - 30

ER -

Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport

Abstract

Keywords

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Synthesis and properties of novel sequen: Synthesis and properties of novel sequentially fluorinated motifs in organcic chemistry

Cite this