Fluoroquinolone-resistant mutants of Burkholdena cepacia

C. F. Pope; S. H. Gillespie; J. R. Pratten; T. D. McHugh

doi:10.1128/AAC.00799-07

Fluoroquinolone-resistant mutants of Burkholdena cepacia

C. F. Pope, S. H. Gillespie, J. R. Pratten, T. D. McHugh

Research output: Contribution to journal › Article › peer-review

Abstract

Fluoroquinolone-resistant Burkholderia cepacia mutants were selected on ciprofloxacin. The rate of mutation in gyrA was estimated to be 9.6 × 10^-11 mutations per division. Mutations in gyrA conferred 12- to 64-fold increases in MIC, and an additional parC mutation conferred a large increase in MIC (>256-fold). Growth rate, biofilm formation, and survival in water and during drying were not impaired in strains containing single gyrA mutations. Double mutants were impaired only in growth rate (0.85, relative to the susceptible parent).

Original language	English
Pages (from-to)	1201-1203
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	3
DOIs	https://doi.org/10.1128/AAC.00799-07
Publication status	Published - 1 Mar 2008

Access to Document

10.1128/AAC.00799-07

Cite this

@article{f0873c61464e48b1a2f9cabee41ead3c,

title = "Fluoroquinolone-resistant mutants of Burkholdena cepacia",

abstract = "Fluoroquinolone-resistant Burkholderia cepacia mutants were selected on ciprofloxacin. The rate of mutation in gyrA was estimated to be 9.6 × 10-11 mutations per division. Mutations in gyrA conferred 12- to 64-fold increases in MIC, and an additional parC mutation conferred a large increase in MIC (>256-fold). Growth rate, biofilm formation, and survival in water and during drying were not impaired in strains containing single gyrA mutations. Double mutants were impaired only in growth rate (0.85, relative to the susceptible parent).",

author = "Pope, {C. F.} and Gillespie, {S. H.} and Pratten, {J. R.} and McHugh, {T. D.}",

year = "2008",

month = mar,

day = "1",

doi = "10.1128/AAC.00799-07",

language = "English",

volume = "52",

pages = "1201--1203",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "3",

}

TY - JOUR

T1 - Fluoroquinolone-resistant mutants of Burkholdena cepacia

AU - Pope, C. F.

AU - Gillespie, S. H.

AU - Pratten, J. R.

AU - McHugh, T. D.

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Fluoroquinolone-resistant Burkholderia cepacia mutants were selected on ciprofloxacin. The rate of mutation in gyrA was estimated to be 9.6 × 10-11 mutations per division. Mutations in gyrA conferred 12- to 64-fold increases in MIC, and an additional parC mutation conferred a large increase in MIC (>256-fold). Growth rate, biofilm formation, and survival in water and during drying were not impaired in strains containing single gyrA mutations. Double mutants were impaired only in growth rate (0.85, relative to the susceptible parent).

AB - Fluoroquinolone-resistant Burkholderia cepacia mutants were selected on ciprofloxacin. The rate of mutation in gyrA was estimated to be 9.6 × 10-11 mutations per division. Mutations in gyrA conferred 12- to 64-fold increases in MIC, and an additional parC mutation conferred a large increase in MIC (>256-fold). Growth rate, biofilm formation, and survival in water and during drying were not impaired in strains containing single gyrA mutations. Double mutants were impaired only in growth rate (0.85, relative to the susceptible parent).

UR - http://www.scopus.com/inward/record.url?scp=40549138069&partnerID=8YFLogxK

U2 - 10.1128/AAC.00799-07

DO - 10.1128/AAC.00799-07

M3 - Article

C2 - 18160522

AN - SCOPUS:40549138069

SN - 0066-4804

VL - 52

SP - 1201

EP - 1203

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

Fluoroquinolone-resistant mutants of Burkholdena cepacia

Abstract

Access to Document

Other files and links

Fingerprint

Cite this