Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya

H Deng, D O'Hagan, C Schaffrath

Research output: Contribution to journalReview articlepeer-review

90 Citations (Scopus)

Abstract

This review outlines the recent developments in uncovering the enzymes and intermediates involved in fluorometabolite biosynthesis in the bacterium Streptomyces cattleya. A particular emphasis is placed on the purification and characterisation of the fluorinase, the C-F bond forming enzyme which initiates the biosynthesis. Nature has hardly developed a biochemistry around fluorine, yet fluorinated organics are important commercial entities, therefore a biotransformation from inorganic to organic fluorine is novel and of contemporary interest.

Original languageEnglish
Pages (from-to)773-784
Number of pages12
JournalNatural Product Reports
Volume21
DOIs
Publication statusPublished - 2004

Keywords

  • FLUOROACETIC ACID
  • CRYSTAL-STRUCTURE
  • ACACIA-GEORGINAE
  • BOND FORMATION
  • ENZYME
  • 4-FLUOROTHREONINE
  • METABOLISM
  • METHIONINE
  • MECHANISM
  • IDENTIFICATION

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