Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

Sheng Huang; Long Ma; Ming Him Tong; Yi Yu; David O'Hagan; Hai Deng

doi:10.1039/c4ob00970c

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

Sheng Huang, Long Ma, Ming Him Tong, Yi Yu^*, David O'Hagan, Hai Deng

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Genome sequencing identified a fluorinase gene in the marine bacterium Streptomyces xinghaiensis NRRL B-24674. Fermentation of the organism with inorganic fluoride (2 mM) demonstrated that the organism could biosynthesise fluoroacetate and that fluoroacetate production is sea-salt dependent. This is the first fluoro-metabolite producing microorganism identified from the marine environment.

Original language	English
Pages (from-to)	4828-4831
Number of pages	4
Journal	Organic & Biomolecular Chemistry
Volume	12
Issue number	27
DOIs	https://doi.org/10.1039/c4ob00970c
Publication status	Published - 2014

Keywords

FLUOROMETABOLITE BIOSYNTHESIS
GENOME SEQUENCE
CATTLEYA
FLUORINASE
IDENTIFICATION
ENZYME
4-FLUOROTHREONINE
SPECIFICITY
SEDIMENT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c4ob00970c

Extending fluorinase C-18F-bond: Extending fluorinase [C-18F]-bond biocatalysis for Positron Emission Tomography (PET)
O'Hagan, D. (PI)
EPSRC
1/11/11 → 31/10/14
Project: Standard

Cite this

@article{033c2bf87d0b40108a45c8006b509ee4,

title = "Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674",

abstract = "Genome sequencing identified a fluorinase gene in the marine bacterium Streptomyces xinghaiensis NRRL B-24674. Fermentation of the organism with inorganic fluoride (2 mM) demonstrated that the organism could biosynthesise fluoroacetate and that fluoroacetate production is sea-salt dependent. This is the first fluoro-metabolite producing microorganism identified from the marine environment.",

keywords = "FLUOROMETABOLITE BIOSYNTHESIS, GENOME SEQUENCE, CATTLEYA, FLUORINASE, IDENTIFICATION, ENZYME, 4-FLUOROTHREONINE, SPECIFICITY, SEDIMENT",

author = "Sheng Huang and Long Ma and Tong, {Ming Him} and Yi Yu and David O'Hagan and Hai Deng",

year = "2014",

doi = "10.1039/c4ob00970c",

language = "English",

volume = "12",

pages = "4828--4831",

journal = "Organic & Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "27",

}

TY - JOUR

T1 - Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

AU - Huang, Sheng

AU - Ma, Long

AU - Tong, Ming Him

AU - Yu, Yi

AU - O'Hagan, David

AU - Deng, Hai

PY - 2014

Y1 - 2014

N2 - Genome sequencing identified a fluorinase gene in the marine bacterium Streptomyces xinghaiensis NRRL B-24674. Fermentation of the organism with inorganic fluoride (2 mM) demonstrated that the organism could biosynthesise fluoroacetate and that fluoroacetate production is sea-salt dependent. This is the first fluoro-metabolite producing microorganism identified from the marine environment.

AB - Genome sequencing identified a fluorinase gene in the marine bacterium Streptomyces xinghaiensis NRRL B-24674. Fermentation of the organism with inorganic fluoride (2 mM) demonstrated that the organism could biosynthesise fluoroacetate and that fluoroacetate production is sea-salt dependent. This is the first fluoro-metabolite producing microorganism identified from the marine environment.

KW - FLUOROMETABOLITE BIOSYNTHESIS

KW - GENOME SEQUENCE

KW - CATTLEYA

KW - FLUORINASE

KW - IDENTIFICATION

KW - ENZYME

KW - 4-FLUOROTHREONINE

KW - SPECIFICITY

KW - SEDIMENT

U2 - 10.1039/c4ob00970c

DO - 10.1039/c4ob00970c

M3 - Article

SN - 1477-0520

VL - 12

SP - 4828

EP - 4831

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 27

ER -

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

Abstract

Keywords

UN SDGs

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Projects

Extending fluorinase C-18F-bond: Extending fluorinase [C-18F]-bond biocatalysis for Positron Emission Tomography (PET)

Cite this