Projects per year
Abstract
A synthesis of two (S)-phenylalanine derivatives is described which have the all-cis, 2,3,5,6-tetrafluorocyclohexyl motif attached to the aromatic ring at the meta and para positions; the para substituted isomer is elaborated into illustrative dipeptides via the free amine and carboxylate respectively demonstrating its utility as a novel amino acid for peptide synthesis and offering a vehicle for incorporation of this unique and facially polarized ring system into bioactive compounds.
Original language | English |
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Pages (from-to) | 5621-5624 |
Journal | Organic & Biomolecular Chemistry |
Volume | 13 |
Issue number | 20 |
Early online date | 15 Apr 2015 |
DOIs | |
Publication status | Published - 28 May 2015 |
Fingerprint
Dive into the research topics of 'Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif'. Together they form a unique fingerprint.Projects
- 2 Finished
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Structuring the Future: Structuring the Future - Underpinning world-leading science in EaStCHEM through cutting edge characterisation
Woollins, J. D. (PI), Ashbrook, S. E. (CoI), Morris, R. E. (CoI) & Slawin, A. M. Z. (CoI)
1/01/13 → 31/03/13
Project: Standard
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Upgrade Small Equipment Base: Small items of research equipment at the University of St Andrews. Supporting a new generation of physical sciences research
Woollins, J. D. (PI)
1/11/12 → 31/03/13
Project: Standard
Datasets
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Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif (dataset)
Salah Ayoup, M. (Creator), Cordes, D. B. (Creator), Slawin, A. M. Z. (Creator) & O'Hagan, D. (Creator), Cambridge Crystallographic Data Centre, 2015
https://dx.doi.org/10.5517/cc14h1pc
Dataset