Fluorinase mediated chemoenzymatic synthesis of [F-18]-fluoroacetate

Xiang-Guo Li; Juozas Domarkasc; David O'Hagan

doi:10.1039/c0cc02264k

Fluorinase mediated chemoenzymatic synthesis of [F-18]-fluoroacetate

Xiang-Guo Li^*, Juozas Domarkasc, David O'Hagan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A novel preparation of sodium [F-18]-fluoroacetate is described where 5'-[F-18]-fluoro-5' -deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [F-18]-fluoride and then oxidation to [F-18]-fluoroacetate by a Kuhn-Roth oxidative degradation.

Original language	English
Pages (from-to)	7819-7821
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	41
DOIs	https://doi.org/10.1039/c0cc02264k
Publication status	Published - 2010

Keywords

2-F-18-FLUOROACETATE
ENZYME
TOOL
C-F-18 BOND FORMATION
PET

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10.1039/c0cc02264k

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title = "Fluorinase mediated chemoenzymatic synthesis of [F-18]-fluoroacetate",

abstract = "A novel preparation of sodium [F-18]-fluoroacetate is described where 5'-[F-18]-fluoro-5' -deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [F-18]-fluoride and then oxidation to [F-18]-fluoroacetate by a Kuhn-Roth oxidative degradation.",

keywords = "2-F-18-FLUOROACETATE, ENZYME, TOOL, C-F-18 BOND FORMATION, PET",

author = "Xiang-Guo Li and Juozas Domarkasc and David O'Hagan",

year = "2010",

doi = "10.1039/c0cc02264k",

language = "English",

volume = "46",

pages = "7819--7821",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "41",

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TY - JOUR

T1 - Fluorinase mediated chemoenzymatic synthesis of [F-18]-fluoroacetate

AU - Li, Xiang-Guo

AU - Domarkasc, Juozas

AU - O'Hagan, David

PY - 2010

Y1 - 2010

N2 - A novel preparation of sodium [F-18]-fluoroacetate is described where 5'-[F-18]-fluoro-5' -deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [F-18]-fluoride and then oxidation to [F-18]-fluoroacetate by a Kuhn-Roth oxidative degradation.

AB - A novel preparation of sodium [F-18]-fluoroacetate is described where 5'-[F-18]-fluoro-5' -deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [F-18]-fluoride and then oxidation to [F-18]-fluoroacetate by a Kuhn-Roth oxidative degradation.

KW - 2-F-18-FLUOROACETATE

KW - ENZYME

KW - TOOL

KW - C-F-18 BOND FORMATION

KW - PET

U2 - 10.1039/c0cc02264k

DO - 10.1039/c0cc02264k

M3 - Article

SN - 1359-7345

VL - 46

SP - 7819

EP - 7821

JO - Chemical Communications

JF - Chemical Communications

IS - 41

ER -

Fluorinase mediated chemoenzymatic synthesis of [F-18]-fluoroacetate

Abstract

Keywords

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