Fluorinase mediated chemoenzymatic synthesis of [F-18]-fluoroacetate

Xiang-Guo Li*, Juozas Domarkasc, David O'Hagan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A novel preparation of sodium [F-18]-fluoroacetate is described where 5'-[F-18]-fluoro-5' -deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [F-18]-fluoride and then oxidation to [F-18]-fluoroacetate by a Kuhn-Roth oxidative degradation.

Original languageEnglish
Pages (from-to)7819-7821
Number of pages3
JournalChemical Communications
Volume46
Issue number41
DOIs
Publication statusPublished - 2010

Keywords

  • 2-F-18-FLUOROACETATE
  • ENZYME
  • TOOL
  • C-F-18 BOND FORMATION
  • PET

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