Fluorinase mediated C-F-18 bond formation, an enzymatic tool for PET labelling

H Deng, S L Cobb, A D Gee, A Lockhart, L Martarello, R P McGlinchey, D O'Hagan, M Onega

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [F-18]-fluoride into [F-18]-5'-fluoro-5'-deoxyadenosine, [F-18]-5'-fluoro-5'-deoxyinosine and [F-18]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.

Original languageEnglish
Pages (from-to)652-654
Number of pages3
JournalChemical Communications
Issue number6
DOIs
Publication statusPublished - 14 Feb 2006

Keywords

  • STREPTOMYCES-CATTLEYA
  • BIOSYNTHESIS
  • MECHANISM
  • ACID

Fingerprint

Dive into the research topics of 'Fluorinase mediated C-F-18 bond formation, an enzymatic tool for PET labelling'. Together they form a unique fingerprint.

Cite this