Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger; Yexuan Deng; Paul Whitney; Ranja Salvamoser; Sven Engel; Andrew J. Kueh; Lin Tai; Annabell Bachem; Elise Gressier; Niall D. Geoghegan; Stephen Wilcox; Kelly L. Rogers; Alexandra L. Garnham; Michael A. Dengler; Stefanie M. Bader; Gregor Ebert; Jaclyn S. Pearson; Dominic De Nardo; Nancy Wang; Chenying Yang; Milton Pereira; Clare E. Bryant; Richard A. Strugnell; James E. Vince; Marc Pellegrini; Andreas Strasser; Sammy Bedoui; Marco J. Herold

doi:10.1016/j.immuni.2020.07.004

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J. Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D. Geoghegan, Stephen Wilcox, Kelly L. Rogers, Alexandra L. Garnham, Michael A. Dengler, Stefanie M. Bader, Gregor Ebert, Jaclyn S. Pearson, Dominic De Nardo, Nancy Wang, Chenying YangMilton Pereira, Clare E. Bryant, Richard A. Strugnell, James E. Vince, Marc Pellegrini, Andreas Strasser^*, Sammy Bedoui^*, Marco J. Herold^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The clearance of intracellular pathogens requires the killing of infected cells, but it remains unclear why host cells have so many different means of inducing programmed cell death. Doerflinger et al. demonstrate that interconnectivity between pyroptosis and apoptosis involving flexible deployment of caspases ensures control of Salmonella infection in mice.

Original language	English
Pages (from-to)	533-547.e7
Journal	Immunity
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2020.07.004
Publication status	Published - 15 Sept 2020

Keywords

apoptosis
caspase-1
caspase-11
caspase-8
cell death
effector caspases
gasdermin D
necroptosis
pyroptosis
Salmonella

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2020.07.004

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Doerflinger, M., Deng, Y., Whitney, P., Salvamoser, R., Engel, S., Kueh, A. J., Tai, L., Bachem, A., Gressier, E., Geoghegan, N. D., Wilcox, S., Rogers, K. L., Garnham, A. L., Dengler, M. A., Bader, S. M., Ebert, G., Pearson, J. S., De Nardo, D., Wang, N., ... Herold, M. J. (2020). Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection. Immunity, 53(3), 533-547.e7. https://doi.org/10.1016/j.immuni.2020.07.004

@article{354d949a154b453f92f49241d24bb998,

title = "Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection",

abstract = "The clearance of intracellular pathogens requires the killing of infected cells, but it remains unclear why host cells have so many different means of inducing programmed cell death. Doerflinger et al. demonstrate that interconnectivity between pyroptosis and apoptosis involving flexible deployment of caspases ensures control of Salmonella infection in mice.",

keywords = "apoptosis, caspase-1, caspase-11, caspase-8, cell death, effector caspases, gasdermin D, necroptosis, pyroptosis, Salmonella",

author = "Marcel Doerflinger and Yexuan Deng and Paul Whitney and Ranja Salvamoser and Sven Engel and Kueh, {Andrew J.} and Lin Tai and Annabell Bachem and Elise Gressier and Geoghegan, {Niall D.} and Stephen Wilcox and Rogers, {Kelly L.} and Garnham, {Alexandra L.} and Dengler, {Michael A.} and Bader, {Stefanie M.} and Gregor Ebert and Pearson, {Jaclyn S.} and {De Nardo}, Dominic and Nancy Wang and Chenying Yang and Milton Pereira and Bryant, {Clare E.} and Strugnell, {Richard A.} and Vince, {James E.} and Marc Pellegrini and Andreas Strasser and Sammy Bedoui and Herold, {Marco J.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = sep,

day = "15",

doi = "10.1016/j.immuni.2020.07.004",

language = "English",

volume = "53",

pages = "533--547.e7",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "3",

}

Doerflinger, M, Deng, Y, Whitney, P, Salvamoser, R, Engel, S, Kueh, AJ, Tai, L, Bachem, A, Gressier, E, Geoghegan, ND, Wilcox, S, Rogers, KL, Garnham, AL, Dengler, MA, Bader, SM, Ebert, G, Pearson, JS, De Nardo, D, Wang, N, Yang, C, Pereira, M, Bryant, CE, Strugnell, RA, Vince, JE, Pellegrini, M, Strasser, A, Bedoui, S & Herold, MJ 2020, 'Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection', Immunity, vol. 53, no. 3, pp. 533-547.e7. https://doi.org/10.1016/j.immuni.2020.07.004

TY - JOUR

T1 - Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

AU - Doerflinger, Marcel

AU - Deng, Yexuan

AU - Whitney, Paul

AU - Salvamoser, Ranja

AU - Engel, Sven

AU - Kueh, Andrew J.

AU - Tai, Lin

AU - Bachem, Annabell

AU - Gressier, Elise

AU - Geoghegan, Niall D.

AU - Wilcox, Stephen

AU - Rogers, Kelly L.

AU - Garnham, Alexandra L.

AU - Dengler, Michael A.

AU - Bader, Stefanie M.

AU - Ebert, Gregor

AU - Pearson, Jaclyn S.

AU - De Nardo, Dominic

AU - Wang, Nancy

AU - Yang, Chenying

AU - Pereira, Milton

AU - Bryant, Clare E.

AU - Strugnell, Richard A.

AU - Vince, James E.

AU - Pellegrini, Marc

AU - Strasser, Andreas

AU - Bedoui, Sammy

AU - Herold, Marco J.

PY - 2020/9/15

Y1 - 2020/9/15

N2 - The clearance of intracellular pathogens requires the killing of infected cells, but it remains unclear why host cells have so many different means of inducing programmed cell death. Doerflinger et al. demonstrate that interconnectivity between pyroptosis and apoptosis involving flexible deployment of caspases ensures control of Salmonella infection in mice.

AB - The clearance of intracellular pathogens requires the killing of infected cells, but it remains unclear why host cells have so many different means of inducing programmed cell death. Doerflinger et al. demonstrate that interconnectivity between pyroptosis and apoptosis involving flexible deployment of caspases ensures control of Salmonella infection in mice.

KW - apoptosis

KW - caspase-1

KW - caspase-11

KW - caspase-8

KW - cell death

KW - effector caspases

KW - gasdermin D

KW - necroptosis

KW - pyroptosis

KW - Salmonella

UR - http://www.scopus.com/inward/record.url?scp=85089386993&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2020.07.004

DO - 10.1016/j.immuni.2020.07.004

M3 - Article

C2 - 32735843

AN - SCOPUS:85089386993

SN - 1074-7613

VL - 53

SP - 533-547.e7

JO - Immunity

JF - Immunity

IS - 3

ER -

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Abstract

Keywords

UN SDGs

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