Flexible organic light-emitting diodes for antimicrobial photodynamic therapy

Cheng Lian; Marta Piksa; Kou Yoshida; Saydulla Persheyev; Krzysztof Pawlik; Katarzyna Matczyszyn; Ifor David William Samuel

doi:10.1038/s41528-019-0058-0

Flexible organic light-emitting diodes for antimicrobial photodynamic therapy

Cheng Lian, Marta Piksa, Kou Yoshida, Saydulla Persheyev, Krzysztof Pawlik, Katarzyna Matczyszyn, Ifor David William Samuel

Research output: Contribution to journal › Article › peer-review

Abstract

Bacterial infection is a serious and growing problem as antibiotic resistance grows leading to patient suffering, death and increased costs of healthcare. To address this problem, we propose using flexible organic light-emitting diodes (OLEDs) as light sources for photodynamic therapy (PDT) to kill bacteria. PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells. We have developed flexible top-emitting flexible OLEDs with the ability to tune the emission peak from 669-737 nm to match the photosensitizer, together with high irradiance, low driving voltage, long operational lifetime and adequate shelflife. These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources. A detailed study of OLED-PDT for killing S. aureus was performed. The results show that our OLEDs in combination with the photosensitizer methylene blue can kill more than 99% of bacteria, which indicates a huge potential for using OLEDs to treat bacterial infections.

Original language	English
Article number	18
Journal	npj Flexible Electronics
Volume	3
Early online date	18 Sept 2019
DOIs	https://doi.org/10.1038/s41528-019-0058-0
Publication status	E-pub ahead of print - 18 Sept 2019

Keywords

Organic light-emitting diodes (OLEDs)
Antimicrobial photodynamic therapy (aPDT)
Flexible electronics
Methylene blue

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CM DTC 2014 - 2022: EPSRC centre for doctoral training in condensed matter physics: Renewal of the CM-DTC
King, P. (PI)
EPSRC
1/08/14 → 31/01/24
Project: Standard
ERC Advanced Grant EXCITON: EU FP7 ERC Advanced Grant 2012 EXCITON
Samuel, I. D. W. (PI)
European Research Council
1/04/13 → 30/03/19
Project: Standard

Flexible Organic Light-Emitting Diodes for Antimicrobial Photodynamic Therapy (dataset)
Lian, C. (Creator), Piksa, M. (Creator), Yoshida, K. (Creator), Persheyev, S. (Creator), pawlik, K. (Creator), Matczyszyn, K. (Creator) & Samuel, I. D. W. (Creator), University of St Andrews, 19 Sept 2019
DOI: 10.17630/918cad79-1d2d-4448-9b25-18b811b1f3ae
Dataset

File

Cite this

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title = "Flexible organic light-emitting diodes for antimicrobial photodynamic therapy",

abstract = "Bacterial infection is a serious and growing problem as antibiotic resistance grows leading to patient suffering, death and increased costs of healthcare. To address this problem, we propose using flexible organic light-emitting diodes (OLEDs) as light sources for photodynamic therapy (PDT) to kill bacteria. PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells. We have developed flexible top-emitting flexible OLEDs with the ability to tune the emission peak from 669-737 nm to match the photosensitizer, together with high irradiance, low driving voltage, long operational lifetime and adequate shelflife. These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources. A detailed study of OLED-PDT for killing S. aureus was performed. The results show that our OLEDs in combination with the photosensitizer methylene blue can kill more than 99% of bacteria, which indicates a huge potential for using OLEDs to treat bacterial infections.",

keywords = "Organic light-emitting diodes (OLEDs), Antimicrobial photodynamic therapy (aPDT), Flexible electronics, Methylene blue",

author = "Cheng Lian and Marta Piksa and Kou Yoshida and Saydulla Persheyev and Krzysztof Pawlik and Katarzyna Matczyszyn and Samuel, {Ifor David William}",

note = "The authors are grateful to the European Research Council (grant 321305) and EPSRC (grant EP/L015110/1) for financial support. The authors would like to acknowledge EU grant Polythea (grant 764837) as well as support from the Polish Ministry of Science and Higher Education for the Faculty of Chemistry of WUT.",

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doi = "10.1038/s41528-019-0058-0",

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T1 - Flexible organic light-emitting diodes for antimicrobial photodynamic therapy

AU - Lian, Cheng

AU - Piksa, Marta

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AU - Persheyev, Saydulla

AU - Pawlik, Krzysztof

AU - Matczyszyn, Katarzyna

AU - Samuel, Ifor David William

N1 - The authors are grateful to the European Research Council (grant 321305) and EPSRC (grant EP/L015110/1) for financial support. The authors would like to acknowledge EU grant Polythea (grant 764837) as well as support from the Polish Ministry of Science and Higher Education for the Faculty of Chemistry of WUT.

PY - 2019/9/18

Y1 - 2019/9/18

N2 - Bacterial infection is a serious and growing problem as antibiotic resistance grows leading to patient suffering, death and increased costs of healthcare. To address this problem, we propose using flexible organic light-emitting diodes (OLEDs) as light sources for photodynamic therapy (PDT) to kill bacteria. PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells. We have developed flexible top-emitting flexible OLEDs with the ability to tune the emission peak from 669-737 nm to match the photosensitizer, together with high irradiance, low driving voltage, long operational lifetime and adequate shelflife. These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources. A detailed study of OLED-PDT for killing S. aureus was performed. The results show that our OLEDs in combination with the photosensitizer methylene blue can kill more than 99% of bacteria, which indicates a huge potential for using OLEDs to treat bacterial infections.

AB - Bacterial infection is a serious and growing problem as antibiotic resistance grows leading to patient suffering, death and increased costs of healthcare. To address this problem, we propose using flexible organic light-emitting diodes (OLEDs) as light sources for photodynamic therapy (PDT) to kill bacteria. PDT involves the use of light and a photosensitizer to generate reactive oxygen species that kill neighbouring cells. We have developed flexible top-emitting flexible OLEDs with the ability to tune the emission peak from 669-737 nm to match the photosensitizer, together with high irradiance, low driving voltage, long operational lifetime and adequate shelflife. These features enable OLEDs to be the ideal candidate for ambulatory PDT light sources. A detailed study of OLED-PDT for killing S. aureus was performed. The results show that our OLEDs in combination with the photosensitizer methylene blue can kill more than 99% of bacteria, which indicates a huge potential for using OLEDs to treat bacterial infections.

KW - Organic light-emitting diodes (OLEDs)

KW - Antimicrobial photodynamic therapy (aPDT)

KW - Flexible electronics

KW - Methylene blue

U2 - 10.1038/s41528-019-0058-0

DO - 10.1038/s41528-019-0058-0

M3 - Article

SN - 2397-4621

VL - 3

JO - npj Flexible Electronics

JF - npj Flexible Electronics

M1 - 18

ER -

Flexible organic light-emitting diodes for antimicrobial photodynamic therapy

Abstract

Keywords

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Projects

CM DTC 2014 - 2022: EPSRC centre for doctoral training in condensed matter physics: Renewal of the CM-DTC

ERC Advanced Grant EXCITON: EU FP7 ERC Advanced Grant 2012 EXCITON

Datasets

Flexible Organic Light-Emitting Diodes for Antimicrobial Photodynamic Therapy (dataset)

Cite this