Five-membered rings with two adjacent heteroatoms with at least one boron

R Alan Aitken, Dheirya Kalpesh Sonecha

Research output: Chapter in Book/Report/Conference proceedingChapter


Developments in the chemistry of five-membered ring heterocycles containing two adjacent heteroatoms, with at least one boron, in the period 2008–2020 are reviewed. Application of theoretical and structural methods to these compounds is described including X-ray structure determination and both 11B and 31P NMR. The major reactions of azaboroline and phosphaborolane systems as well as their benzo analogues are discussed. Reactions and applications of benzoxaborolols have been extensively investigated related to the medicinal activity of these compounds. Chemistry of 1,2-diborole compounds has also developed significantly Methods for the synthesis of all the compounds are systematically covered. Most of the systems containing boron and phosphorus have only been reported recently and were not included in previous editions of Comprehensive Heterocyclic Chemistry.
Original languageEnglish
Title of host publicationComprehensive heterocyclic chemistry IV - a review of the literature 2008-2021
Subtitle of host publicationVolume 4 - Five-membered rings with two heteroatoms, and their fused carbocyclic derivatives
EditorsR. A. Aitken
Place of PublicationAmsterdam
PublisherElsevier (incl. Pergamon )
Number of pages22
ISBN (Electronic)9780128186565
ISBN (Print)9780323912679, 9780128186558
Publication statusPublished - 23 Nov 2022


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