Abstract
The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted into the corresponding eight-membered lactones and seven- and eight-membered lactams in good to excellent yields. (c) 2005 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 4027-4030 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 23 |
DOIs | |
Publication status | Published - 6 Jun 2005 |
Keywords
- radical
- phosphorus
- DEPO
- EPHP
- cyclisation
- KETYL-OLEFIN CYCLIZATION
- CARBON BOND FORMATION
- (ALKOXYCARBONYL)METHYL RADICALS
- STEREOSELECTIVE-SYNTHESIS
- 8-ENDO CYCLIZATION
- EFFICIENT ROUTE
- AQUEOUS-MEDIA
- HYPOPHOSPHITE
- WATER
- ESTERS