Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression

Yanghua Wang; Adam Gersten; Susana Moleirinho; Frank Gunn-Moore; Paul Andrew Reynolds; Michael Prystowsky

doi:10.1177/2374289515616972

Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression

Yanghua Wang, Adam Gersten, Susana Moleirinho, Frank Gunn-Moore, Paul Andrew Reynolds, Michael Prystowsky

Research output: Contribution to journal › Article › peer-review

Abstract

We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.

Original language	English
Number of pages	5
Journal	Academic Pathology
Volume	2
Issue number	4
Early online date	26 Nov 2015
DOIs	https://doi.org/10.1177/2374289515616972
Publication status	Published - Dec 2015

Keywords

Squamous cell carcinoma
perineural invasion
YAP expression
fibroblast

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/2374289515616972

Wang et al 2015Accepted author manuscript, 1.13 MBLicence: CC BY-NC
Academic Pathology-2015-Wang-CC
Copyright The Authors 2015. Creative Commons CC-BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Final published version, 684 KBLicence: CC BY-NC

Role of CRB3: Role of CRB3 in epithelial junctions and in head and neck cancer
Reynolds, P. A. (PI)
16/09/15 → 15/09/16
Project: Standard

Cite this

@article{1f691b8fc1d846ee9e1133df24c1b10b,

title = "Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression",

abstract = "We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.",

keywords = "Squamous cell carcinoma, perineural invasion, YAP expression, fibroblast",

author = "Yanghua Wang and Adam Gersten and Susana Moleirinho and Frank Gunn-Moore and Reynolds, {Paul Andrew} and Michael Prystowsky",

note = "Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer. ",

year = "2015",

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doi = "10.1177/2374289515616972",

language = "English",

volume = "2",

journal = "Academic Pathology",

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TY - JOUR

T1 - Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression

AU - Wang, Yanghua

AU - Gersten, Adam

AU - Moleirinho, Susana

AU - Gunn-Moore, Frank

AU - Reynolds, Paul Andrew

AU - Prystowsky, Michael

N1 - Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.

PY - 2015/12

Y1 - 2015/12

N2 - We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.

AB - We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.

KW - Squamous cell carcinoma

KW - perineural invasion

KW - YAP expression

KW - fibroblast

U2 - 10.1177/2374289515616972

DO - 10.1177/2374289515616972

M3 - Article

SN - 2374-2895

VL - 2

JO - Academic Pathology

JF - Academic Pathology

IS - 4

ER -

Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression

Abstract

Keywords

UN SDGs

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Projects

Role of CRB3: Role of CRB3 in epithelial junctions and in head and neck cancer

Cite this